930555

Pomalidomide-piperazine-acetic acid

≥95%

• Synonym(s): 2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)acetic acid, {4-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]piperazin-1-yl}acetic acid
• Empirical Formula (Hill Notation): C₁₉H₂₀N₄O₆
• CAS Number: 2591180-39-9
• Molecular Weight: 400.39
• UNSPSC Code: 12352106
• NACRES: NA.21
• MDL number: MFCD34570945

Properties

• ligand: pomalidomide
• Quality Segment: 100
• assay: ≥95%
• form: powder
• technique(s): targeted protein degradation: suitable
• functional group: carboxylic acid
• storage temp.: 2-8°C
• SMILES string: O=C(O)CN1CCN(C2=CC=C3C(=O)N(C(=O)C3=C2)C4C(=O)NC(=O)CC4)CC1
• InChI: 1S/C19H20N4O6/c24-15-4-3-14(17(27)20-15)23-18(28)12-2-1-11(9-13(12)19(23)29)22-7-5-21(6-8-22)10-16(25)26/h1-2,9,14H,3-8,10H2,(H,25,26)(H,20,24,27)
• InChI key: KKROJYHJCUOZOJ-UHFFFAOYSA-N

Description

Application

Pomalidomide-piperazine-acetic acid is a functionalized cereblon ligand for development of pomalidomide-based PROTACs. Allows rapid conjugation with amine linkers due to the presence of a carboxyl group via peptide coupling reactions. A basic building block for development of a protein degrader library.


Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Other Notes

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Codes: H360D
• Precautionary Statements: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable