925225

KB02yne

• Synonym(s): 2-Chloro-1-(6-(hex-5-yn-1-yloxy)-3,4-dihydroquinolin-1(2H)-yl)ethan-1-one, Functionalized scout fragment
• Empirical Formula (Hill Notation): C₁₇H₂₀ClNO₂
• CAS Number: 2376152-06-4
• Molecular Weight: 305.80
• MDL number: MFCD00003568
• NACRES: NA.22
• UNSPSC Code: 12352101

Properties

• form: powder or crystals (or Solid or Liquid)
• Quality Segment: 100
• reaction suitability: reagent type: chemical modification reagent; reaction type: click chemistry
• storage temp.: 2-8°C

Description

Application

KB02yne is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as ″undruggable,″ or difficult-to-target, proteins. This fragment electrophile is the functionalized version of KB02 (912131).

Related useful products may include:

• Cysteine-reactive fragments: KB02 (912131), KB03 (912654), KB05 (911798), sulfoxide (925136), CoLDR probe (923818)
• Functionalized scout fragments: KB02-COOH (925047), KB05yne (925144)
• Electrophilc degraders featuring scout fragments: KB02-SLF (914738), KB03-SLF (914975), KB05-SLF (913715), Biotin-SLF (914223)
• Cysteine-reactive probes for chemoproteomics: IA alkyne (924237), IA 5-TAMRA (925020), desthiobiotin iodoacetamide (923826), or biotin iodoacetamide (B2059)

Technology spotlight: Proteomic Ligandability Assessment

Other Notes

Functionalized Scout Fragments for Site-Specific Covalent Ligand Discovery and Optimization

The Proteome-Wide Potential for Reversible Covalency at Cysteine

Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16

Safety Information

• Storage Class: 10 - Combustible liquids
• WGK: WGK 3