902241
N-Hydroxysuccinimide poly(ethylene glycol)-block-poly(lactide-co-glycolide)
PEG average Mn 5000, PLGA average Mn 15000, lactide:glycolide 50:50
Synonym(s):
NHS-PEG-b-PLGA, NHS-PEG-PLGA
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About This Item
Linear Formula:
C10H14O5NS(C2H4O)nC2H4O[(C2H2O2)x(C3H4O2)y]mH
UNSPSC Code:
12352111
NACRES:
NA.23
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form
powder
feed ratio
lactide:glycolide 50:50
lactide:glycolide 50:50±5
mol wt
PEG Mn 4000-6000 g/mol (by NMR)
PEG average Mn 5000
PLGA Mn 13500-16500 g/mol (by NMR)
PLGA average Mn 15000
color
white
suitability
conforms to structure for NMR
storage temp.
−20°C
Related Categories
Application
N-Hydroxysuccinimide poly(ethylene glycol)-block-poly(lactide-co-glycolide) is a N-hydroxysuccinimide (NHS)-functionalized, biocompatible, amphiphilic block copolymer. Due to its self-assembling properties, this material can be used in the formation of nanoparticles for drug delivery. Additionally, due to the NHS-functionalization of the PEG block, this material can be used to rapidly covalently conjugate biomolecules, API, or targeting ligands. Potential uses include the targeted and/or controlled release of cancer drugs, anti-inflammatory drugs, antibiotics, or anesthetic agents.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Biodegradable PLGA-b-PEG polymeric nanoparticles: synthesis, properties and nanomedical applications as drug delivery system
Locatelli, E. et al.
Journal of Nanoparticle Research, 14, 1316-1316 (2012)
Aptamer Functionalization of Nanosystems for Glioblastoma Targeting through the Blood-Brain Barrier.
Ilaria Monaco et al.
Journal of medicinal chemistry, 60(10), 4510-4516 (2017-05-05)
Polymeric nanoparticles (PNPs) may efficiently deliver in vivo therapeutics to tumors when conjugated to specific targeting agents. Gint4.T aptamer specifically recognizes platelet-derived growth factor receptor β and can cross the blood-brain barrier (BBB). We synthesized Gint4.T-conjugated PNPs able of high
Yihan Xu et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 105(6), 1692-1716 (2016-04-22)
Poly (lactic-co-glycolic acid) (PLGA) copolymers have been broadly used in controlled drug release applications. Because these polymers are biodegradable, they provide an attractive option for drug delivery vehicles. There are a variety of material, processing, and physiological factors that impact
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