901941

Thiol poly(ethylene glycol)-block-poly(lactide-co-glycolide)

PEG average M_n 5,000, PLGA average M_n 15,000, lactide:glycolide 50:50

• Synonym(s): Thiol-PEG-b-PLGA, Thiol-PEG-PLGA
• Linear Formula: C₃H₇SO(C₂H₄O)_nC₂H₄O[(C₂H₂O₂)_x(C₃H₄O₂)_y]_m
• NACRES: NA.23
• UNSPSC Code: 51171641

Properties

• description: Identity: Conforms to structure
• form: powder
• feed ratio: lactide:glycolide 50:50, lactide:glycolide 50:50±5 (by NMR)
• mol wt: PEG M_n 4000-6000 g/mol (by NMR), PEG average M_n 5,000, PLGA M_n 13500-16500 g/mol (by NMR), PLGA average M_n 15,000
• color: white
• storage temp.: −20°C

Description

Application

Thiol poly(ethylene glycol)-block-poly(lactide-co-glycolide) is a thiol-functionalized, biocompatible, amphiphilic block copolymer. Due to its self-assembling properties, this material can be used in the formation of nanoparticles for drug delivery. Additionally, due to the thiol-functionalization of the PEG block, this material can be used to rapidly covalently conjugate biomolecules, API, or targeting ligands. Potential uses include the targeted and/or controlled release of cancer drugs, anti-inflammatory drugs, antibiotics, or anaesthetic agents.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable