901215

Ephos

≥95%, powder or crystals

• Synonym(s): Dicyclohexyl(3-isopropoxy-2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphane
• Empirical Formula (Hill Notation): C₃₆H₅₅OP
• CAS Number: 2118959-55-8
• Molecular Weight: 534.80
• MDL number: MFCD31619192
• UNSPSC Code: 12352128
• NACRES: NA.22

Properties

• Product Name: Ephos, ≥95%
• Quality Segment: 100
• product line: Buchwald Ligand
• assay: ≥95%
• form: powder or crystals
• reaction suitability: reaction type: Buchwald-Hartwig Cross Coupling Reaction, reaction type: Heck Reaction, reaction type: Hiyama Coupling, reaction type: Negishi Coupling, reaction type: Sonogashira Coupling, reaction type: Stille Coupling, reaction type: Suzuki-Miyaura Coupling, reagent type: catalyst; reaction type: Cross Couplings, reagent type: ligand
• greener alternative product score: old score: 41; new score: 28; Find out more about DOZN™ Scoring
• sustainability: Sustainability features
• mp: 161-162 °C
• functional group: phosphine
• SMILES string: P(C4CCCCC4)(C3CCCCC3)c1c(cccc1c2c(cc(cc2C(C)C)C(C)C)C(C)C)OC(C)C
• InChI: 1S/C36H55OP/c1-24(2)28-22-32(25(3)4)35(33(23-28)26(5)6)31-20-15-21-34(37-27(7)8)36(31)38(29-16-11-9-12-17-29)30-18-13-10-14-19-30/h15,20-27,29-30H,9-14,16-19H2,1-8H3
• InChI key: FDAKNRLXSJBEFL-UHFFFAOYSA-N

Description

General description

We are committed to bringing you Greener Alternative Products that adhere to one of the four categories of Greener Alternatives. This product belongs to the category of Re-engineered Products, demonstrating key improvements in Green Chemistry Principles such as "Atom Economy", "Safer Solvents and Auxiliaries", and "Inherently Safer Chemistry for Accident Prevention". Click here to view its DOZN scorecard.

Application

Buchwald ligand for Pd-catalyzed C–N cross-coupling between primary amines and aryl
halides to form 2-arylaminooxazoles. Catalyst system was reported with NaOPh (CDS001581).

Ephos can be used as a ligand in the palladium-catalyzed synthesis of 4-arylaminothiazoles and 2-arylaminooxazoles.

Other Notes

Mechanistic Insight Leads to a Ligand That Facilitates the Pd-Catalyzed Formation of 2-(Hetero)Arylaminooxazoles and 4-(Hetero)Arylaminothiazoles

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable