373605

6,6′-Dithiodinicotinic acid

technical grade, 85%

• Synonym(s): Bis[3-Carboxypyridine] 6,6′-disulfide, Bis[3-carboxypyridine] 6,6′-disulfide
• Empirical Formula (Hill Notation): C₁₂H₈N₂O₄S₂
• CAS Number: 15658-35-2
• Molecular Weight: 308.33
• NACRES: NA.22
• PubChem Substance ID: 24863248
• UNSPSC Code: 12352100
• EC Number: 239-729-6
• MDL number: MFCD00006454
• Assay: 85%
• Form: solid

Properties

• grade: technical grade
• Quality Segment: 200
• assay: 85%
• form: solid
• mp: 263-265 °C (lit.)
• functional group: carboxylic acid, disulfide
• SMILES string: OC(=O)c1ccc(SSc2ccc(cn2)C(O)=O)nc1
• InChI: 1S/C12H8N2O4S2/c15-11(16)7-1-3-9(13-5-7)19-20-10-4-2-8(6-14-10)12(17)18/h1-6H,(H,15,16)(H,17,18)
• InChI key: GSASOFRDSIKDSN-UHFFFAOYSA-N

Description

General description

6,6′-Dithiodinicotinic acid is reported as sulphydryl reagent.[1] 6,6′-Dithiodinicotinic acid is reported to react with thiols, to afford a disulfide and 6-mercaptonicotinic acid.[2] Interaction of 6,6′-dithiodinicotinic acid with the homogenates of Ehrlich ascites cells has been reported.[2]

Application

6,6′-Dithiodinicotinic acid may be employed as:

• specific thiol blocker to investigate the radioprotective effect of mercaptoethylamine on the thiol level of the outer cell membrane of the Ehrlich ascites tumor cells[3]
• modifier to investigate the polar microenvironment around the reactive Cys283 of rabbit muscle creatine kinase[1]
• dipyridyl-dithio substrate to evaluate the protein disulfide-thiol interchange activity of the auxin stimulated NADH: protein disulfide reductase (NADH oxidase) of soybean plasma membranes[4]
• water-soluble reagent in a study for introducing, in buffered saline, a reactive sulfhydryl group on water-soluble molecules bearing an alkyl-amino group[5]
• chromogen for sulfhydryl groups in the Ellman method for cholinesterase determinations[6]
• spectrophotometric determination of thiols and of total glutathione in human blood[7]

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves