23181

Chloromethyl chloroformate

≥98.0% (GC)

• Synonym(s): 1-Chloromethyl chloroformate, Chloroformic acid chloromethyl ester, Chloromethoxycarbonyl chloride, Chloromethyl carbonochloridate, Chloromethyl chlorocarbonate
• Linear Formula: ClCOOCH₂Cl
• CAS Number: 22128-62-7
• Molecular Weight: 128.94
• UNSPSC Code: 12352100
• NACRES: NA.22
• PubChem Substance ID: 57648023
• EC Number: 244-793-3
• Beilstein/REAXYS Number: 506426
• MDL number: MFCD00077688
• Assay: ≥98.0% (GC)
• Form: liquid

Properties

• Quality Segment: 200
• assay: ≥98.0% (GC)
• form: liquid
• refractive index: n20/D 1.428
• bp: 107-108 °C (lit.)
• density: 1.450 g/mL at 20 °C
• functional group: chloro
• storage temp.: 2-8°C
• SMILES string: ClCOC(Cl)=O
• InChI: 1S/C2H2Cl2O2/c3-1-6-2(4)5/h1H2
• InChI key: JYWJULGYGOLCGW-UHFFFAOYSA-N

Description

Application

Chloromethyl chloroformate was used as key reactant in the synthesis of:

• novel aminocarbonyloxymethyl esters of diclofenac and flufenamic acid
• highly water-soluble monomethoxypoly(ethyleneglycol) prodrugs of cyclosporin A
• series of 3-acyloxymethyloxycarbonyl-1-aryl-3-methyltriazenes

Safety Information

• Pictograms: GHS06,GHS05
• Signal Word: Danger
• Hazard Codes: H314,H331
• Precautionary Statements: P261 - P271 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Inhalation - Skin Corr. 1B
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): 203.0 °F - closed cup
• Flash Point (°C): 95 °C - closed cup
• PPE (personal protective equipment): Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter