14462

(−)-α-Bisabolol

≥93% (GC)

• Synonym(s): (-)-alpha-Bisabolol, (−)-6-Methyl-2-(4-methyl-3-cyclohexen-1-yl)-5-hepten-2-ol, Levomenol
• Empirical Formula (Hill Notation): C₁₅H₂₆O
• CAS Number: 23089-26-1
• Molecular Weight: 222.37
• NACRES: NA.22
• PubChem Substance ID: 57647161
• UNSPSC Code: 12352100
• EC Number: 208-205-9
• MDL number: MFCD03412455
• Assay: ≥93% (GC)

Properties

• Quality Segment: 100
• assay: ≥93% (GC)
• optical activity: [α]/D -58±5°, neat
• refractive index: n20/D 1.496
• functional group: hydroxyl
• SMILES string: C\C(C)=C\CC[C@](C)(O)[C@H]1CCC(C)=CC1
• InChI: 1S/C15H26O/c1-12(2)6-5-11-15(4,16)14-9-7-13(3)8-10-14/h6-7,14,16H,5,8-11H2,1-4H3/t14-,15+/m1/s1
• InChI key: RGZSQWQPBWRIAQ-CABCVRRESA-N

Description

General description

(-)-α-Bisabolol is the major constituent of essential oil from leaves of Hymenocrater yazdianus.

Application

(-)-α-Bisabolol was used to investigate the leishmanicidal and cytotoxic activity of essential oil of Vanillosmopsis arborea.

Biochem/physiol Actions

α-Bisabolol is active against primary acute leukemia cells, including BCR-ABL(+) acute lymphoblastic leukemias. It is the inhibitor of voltage-dependent Ca(2+) channels in tracheal smooth muscle preparations of rat. It also inhibits human and rat glioma cell growth and survival. It is a potential new therapeutic agent against leishmaniasis.

Safety Information

• Hazard Codes: H412
• Precautionary Statements: P273 - P501
• Hazard Classifications: Aquatic Chronic 3
• Storage Class: 10 - Combustible liquids
• Flash Point (°F): 289.4 °F - closed cup
• Flash Point (°C): 143 °C - closed cup
• PPE (personal protective equipment): Eyeshields, Gloves