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132225

Troger′s Base

98%

Synonym(s):

2,8-Dimethyl-6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine

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About This Item

Empirical Formula (Hill Notation):
C17H18N2
CAS Number:
529-81-7
Molecular Weight:
250.34
MDL number:
MFCD00134397
UNSPSC Code:
12352100
PubChem Substance ID:
24847554
NACRES:
NA.22

Assay

98%

form

powder

technique(s)

photometry: suitable

mp

133-136 °C (lit.)

SMILES string

Cc1ccc2[N@@H]3C[N@@H](Cc2c1)c4ccc(C)cc4C3

InChI

1S/C17H18N2/c1-12-3-5-16-14(7-12)9-18-11-19(16)10-15-8-13(2)4-6-17(15)18/h3-8H,9-11H2,1-2H3

InChI key

SXPSZIHEWFTLEQ-UHFFFAOYSA-N

Related Categories

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Junjie Ou et al.
Journal of biochemical and biophysical methods, 70(1), 71-76 (2006-09-19)
Two chiral compounds, Tröger's base and tetrahydropalmatine, were enantioseparated on the (5S, 11S)-(-)-Tröger's base and l-tetrahydropalmatine imprinted monolithic capillary columns with CEC, respectively. The monoliths were prepared by in situ thermal-initiated copolymerization of methacrylic acid (MAA) and ethylene dimethacrylate (EDMA).
Xin Du et al.
Chemical communications (Cambridge, England), 46(6), 970-972 (2010-01-29)
An organic nanoporous polymer (BET surface area of 750 m(2) g(-1)) containing bicovalently-bonded Tröger's base as functional moieties in the network was synthesized, characterised, and further applied as a promising heterogeneous catalyst in the addition reaction of diethylzinc to aromatic
Carlos A M Abella et al.
The Journal of organic chemistry, 72(11), 4048-4054 (2007-05-03)
Using direct infusion electrospray ionization mass and tandem mass spectrometric experiments [ESI-MS(/MS)], we have performed on-line monitoring of some reactions used to form Tröger's bases. Key intermediates, either as cationic species or as protonated forms of neutral species, have been
Tröger's-base-derived infinite co-ordination polymer microparticles.
You-Moon Jeon et al.
Small (Weinheim an der Bergstrasse, Germany), 5(1), 46-50 (2008-12-06)
R A Johnson et al.
Journal of medicinal chemistry, 36(21), 3202-3206 (1993-10-15)
The synthesis of 2,8-dimethyl-6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine (Tröger's base) from p-toluidine and of two Tröger's base analogs from other anilines by reaction with hexamethylenetetramine in trifluoroacetic acid is described. 2,3,6,7-Tetrahydro-9-methyl-2,6-di-p-tolyl-1H,5H-pyrimido[5,6,1-ij] quinazoline is formed as a secondary product in the reaction of p-toluidine and
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