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126462

Sigma-Aldrich

6,7-Dimethyl-2,3-di(2-pyridyl)quinoxaline

98%

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About This Item

Empirical Formula (Hill Notation):
C20H16N4
CAS Number:
6627-38-9
Molecular Weight:
312.37
EC Number:
229-592-0
MDL number:
MFCD00006730
UNSPSC Code:
12352100
PubChem Substance ID:
24847727
NACRES:
NA.22

Quality Level

100

Assay

98%

form

powder

mp

191-193 °C (lit.)

SMILES string

Cc1cc2nc(-c3ccccn3)c(nc2cc1C)-c4ccccn4

InChI

1S/C20H16N4/c1-13-11-17-18(12-14(13)2)24-20(16-8-4-6-10-22-16)19(23-17)15-7-3-5-9-21-15/h3-12H,1-2H3

InChI key

NACXMBPTPBZQHY-UHFFFAOYSA-N

Related Categories

Application

6,7-Dimethyl-2,3-di-(2-pyridyl)quinoxaline has been used as an internal standard to investigate the clinical pharmacokinetics of nelfinavir mesylate, a potent inhibitor of HIV-1 protease.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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E Y Wu et al.
Journal of chromatography. B, Biomedical sciences and applications, 695(2), 373-380 (1997-08-01)
Nelfinavir mesylate, a potent and orally bioavailable inhibitor of HIV-1 protease (Ki=2 nM), has undergone Phase III clinical evaluation in a large population of HIV-positive patients. A high-performance liquid chromatography analytical method was developed to determine the pharmacokinetic parameters of
Salmaan Kanji et al.
Clinical pharmacokinetics, 59(3), 327-334 (2019-09-01)
Sustained low-efficiency dialysis (SLED) is a hybrid form of dialysis that is increasingly used in critically ill patients with kidney injury and hemodynamic instability. Antimicrobial dosing for patients receiving SLED is informed by pharmacokinetic studies that describe the drug clearance.
B Louveau et al.
Biomedical chromatography : BMC, 30(12), 2009-2015 (2016-06-10)
A precise and accurate high-performance liquid chromatography (HPLC) quantification method of rifampicin in human plasma was developed and validated using ultraviolet detection after an automatized solid-phase extraction. The method was validated with respect to selectivity, extraction recovery, linearity, intra- and
Valeria Avataneo et al.
The Journal of antimicrobial chemotherapy, 75(7), 1772-1777 (2020-05-04)
Remdesivir has received significant attention for its potential application in the treatment of COVID-19, caused by SARS-CoV-2. Remdesivir has already been tested for Ebola virus disease treatment and found to have activity against SARS and MERS coronaviruses. The remdesivir core
Sara Baldelli et al.
Therapeutic drug monitoring, 36(6), 739-745 (2014-04-18)
Recently, the European Medicines Agency (EMA) has released new guidelines on the validation of bioanalytical methods. In this work, we compared the analytical performance of 2 high-performance liquid chromatography with tandem mass spectrometry methods designed for the quantification of the

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