Guanidine is a strong organic base, making SRE0066 an aqueous solution. In technical terms, guanidine has a pKa of 13.6, indicating that it is a strong basic buffer.
SRE0066
Guanidine hydrochloride solution, 6M
Synonym(s):
Aminoformamidine hydrochloride, GuHCl, Guanidinium chloride, Guanidium chloride
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About This Item
UNSPSC Code:
12352209
NACRES:
NA.25
Pricing and availability is not currently available.
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form
liquid
Quality Level
concentration
6 M
application(s)
diagnostic assay manufacturing
storage temp.
room temp
Related Categories
Application
Guanidine hydrochloride is commonly used as a denaturant, because of its ability to break hydrogen bonds between amino acid residues. By breaking these bonds, the 3D conformation of the protein is unfolded and the aqueous solubility of the protein is greatly increased. Once denatured, the protein can be easily reduced, modified, or analyzed, in a variety of procedures. Further processing of the sample can allow the proteins to be analyzed by other common protein analysis methods including mass spectrometry, electrophoresis, and enzymatic digests.
Guanidine hydrochloride has also typically been used for the isolation of RNA, to denature globular proteins, and for protein refolding studies. It can also be used to facilitate the generation of tryptic peptides for analysis of complex protein samples.
Guanidine hydrochloride has also typically been used for the isolation of RNA, to denature globular proteins, and for protein refolding studies. It can also be used to facilitate the generation of tryptic peptides for analysis of complex protein samples.
Physical form
This product is a ready-to-use 6 M guanidine hydrochloride solution. The 6 M Guanidine hydrochloride solution may be used as a stock solution to prepare solutions of lower concentrations as appropriate.
Note: If precipitation is present in the 6 M buffer, warm the bottle to 37 °C and mix until completely dissolved prior to use.
Note: If precipitation is present in the 6 M buffer, warm the bottle to 37 °C and mix until completely dissolved prior to use.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Is the aqueous solution of guanidine HCl considered a buffer, or is it prepared as an aqueous solution and not in a buffer?
1 answer-
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What is the container plastic type for SRE0066-4L?
1 answer-
The item is packaged in a polyethylene terephthalate glycol container.
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