SAB4300464
Anti-APP (Ab-668) antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Anti-AAA antibody produced in rabbit, Anti-ABETA antibody produced in rabbit, Anti-ABPP antibody produced in rabbit, Anti-AD1 antibody produced in rabbit, Anti-amyloid beta (A4) precursor protein antibody produced in rabbit
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All Photos(2)
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
100-140 kDa
species reactivity
human, mouse, rat
concentration
1 mg/mL
technique(s)
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
( A-V-T-P-E)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... APP(351)
General description
Amyloid β precursor protein (APP) is a type I transmembrane glycoprotein. The APP gene is mapped to human chromosome 21q21.3 and encodes various isoforms due to alternative splicing events. APP displays the ubiquitous expression, although, high levels are observed in the brain. It comprises a large ectodomain, short cytoplasmic tail, E1, and E2 domains. The E1 domain harbors a growth factor-like domain (GFLD) and a copper-binding domain (CuBD).
Immunogen
Peptide sequence around aa. 666-670 ( A-V-T-P-E ), according to the protein APP.
Application
Anti-APP (Ab-668) antibody produced in rabbit has been used in:
- immunohistochemistry
- immunolabeling
- western blotting
- immunoprecipitation
Biochem/physiol Actions
Amyloid β precursor protein (APP) serves as a precursor of amyloid β (Aβ) peptide. It participates in synaptic function, trans-cellular synaptic adhesion, and in the anterograde transport of the virus.
Features and Benefits
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Target description
APP encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Prasanna Satpute-Krishnan et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(44), 16532-16537 (2006-10-26)
Fast anterograde transport of membrane-bound organelles delivers molecules synthesized in the neuronal cell body outward to distant synapses. Identification of the molecular "zipcodes" on organelles that mediate attachment and activation of microtubule-based motors for this directed transport is a major
SnapShot: genetics of Alzheimer's disease.
Rita Guerreiro et al.
Cell, 155(4), 968-968 (2013-11-12)
Eglė Jakubauskienė et al.
Gene, 766, 145146-145146 (2020-09-18)
The removal of introns from mRNA precursors (pre-mRNAs) is an essential step in eukaryotic gene expression. The splicing machinery heavily contributes to biological complexity and especially to the ability of cells to adapt to altered cellular conditions. Hypoxia also plays
Rui Zhang et al.
CNS neuroscience & therapeutics, 26(2), 228-239 (2019-08-01)
As a normal physiological process, sleep has recently been shown to facilitate clearance of macromolecular metabolic wastes from the brain via the glymphatic system. The aim of the present study was to investigate pathophysiological roles of astroglial aquaporin 4 (AQP4)
Jenna M Ramaker et al.
Frontiers in molecular neuroscience, 9, 130-130 (2016-12-10)
Proteolytic processing of the Amyloid Precursor Protein (APP) produces beta-amyloid (Aβ) peptide fragments that accumulate in Alzheimer's Disease (AD), but APP may also regulate multiple aspects of neuronal development, albeit via mechanisms that are not well understood. APP is a
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