ED50 = 1 ng/ml on A20 cells. Does not require any enhancer, as the modified linker sequence already facilitates the formation of active FasL complexes. rhsSuperFas Ligand™ recognizes its receptor Fas (CD95) of the following species: human, rat, mouse.
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Fas ligand has also been shown to be involved in the activation of non-apoptotic pathways including proliferation and NF-κ B activation. [1]
Fas ligand, a protein belonging to the tumor necrosis factor (TNF) family of cytokines, induces apoptosis in cells expressing the cell membrane receptor Fas (CD95/Apo-1).
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SuperFas Ligand is a trademark of Alexis Biochemicals Corp.
Fas (Apo-1, CD95) and Fas-Ligand (FasL, CD95L) are typical members of the TNF receptor and TNF ligand family, respectively, with a pivotal role in the regulation of apoptotic processes, including activation-induced cell death, T-cell-induced cytotoxicity, immune privilege and tumor surveillance.
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