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Key Documents

P8908

Sigma-Aldrich

Prostaglandin E1

synthetic, powder, BioReagent, suitable for cell culture

Synonym(s):

(11α,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoic acid, Alprostadil, PGE1

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About This Item

Empirical Formula (Hill Notation):
C20H34O5
CAS Number:
Molecular Weight:
354.48
Beilstein:
5294062
EC Number:
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic

Quality Level

product line

BioReagent

Assay

≥98% (HPLC)

form

powder

potency

0.25-100 ng/mL

technique(s)

cell culture | mammalian: suitable

solubility

acetone: 10 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C1

InChI

1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1

InChI key

GMVPRGQOIOIIMI-DWKJAMRDSA-N

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General description

Prostaglandin E1 (PGE1) is a vasodilator.

Application

Prostaglandin E1 may be used in cell culture to protect human umbilical vein endothelial cells (HUVEC) from injury induced by hydrogen peroxide.

Biochem/physiol Actions

Prostaglandin E1 (PGE1) aids in the relaxation of corporal cavernosal tissue. It helps to preserve the patency of the ductus arteriosus. It is used to treat erectile dysfunction (ED).

Physical form

powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Prostaglandin E1 for treatment of erectile dysfunction
Urciuoli R, et al.
Cochrane database of systematic reviews (Online), Cochrane(Database), Syst-Syst (2004)
Cardiac Physiology and Pharmacology
A Practice of Anesthesia for Infants and Children, 424-457 (2019)
Corticotrophins, corticosteroids, and prostaglandins
Side Effects of Drugs Annual, 32, 723-733 (2010)
Vasculogenic Erectile Dysfunction
Vascular Medicine: A Companion to Braunwald's Heart Disease, 341-348 (2013)
David Furman et al.
Nature medicine, 23(2), 174-184 (2017-01-17)
Low-grade, chronic inflammation has been associated with many diseases of aging, but the mechanisms responsible for producing this inflammation remain unclear. Inflammasomes can drive chronic inflammation in the context of an infectious disease or cellular stress, and they trigger the

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