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M3199

Sigma-Aldrich

MK-212 hydrochloride

≥98% (HPLC)

Synonym(s):

2-Chloro-6-(1-piperazinyl)-pyrazine hydrochloride, 6-Chloro-2-(1-piperazinyl)pyrazine hydrochloride, NSC 31732

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About This Item

Empirical Formula (Hill Notation):
C8H11ClN4·HCl
CAS Number:
61655-58-1
Molecular Weight:
235.11
EC Number:
262-883-0
MDL number:
MFCD00673963
UNSPSC Code:
12352200
PubChem Substance ID:
329817966
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

SMILES string

Cl.Clc1cncc(n1)N2CCNCC2

InChI

1S/C8H11ClN4.ClH/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13;/h5-6,10H,1-4H2;1H

InChI key

PFIZGLUIYAZQFU-UHFFFAOYSA-N

Biochem/physiol Actions

Selective 5-HT2C serotonin receptor agonist.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Martilias Farrell et al.
Psychopharmacology, 211(2), 149-159 (2010-06-08)
The extended ternary complex theory of receptor function states a ligand can be classified as an inverse agonist, agonist, or neutral antagonist based on its ability to preferentially stabilize the inactive conformation, the active conformation, or to have no preference
E G Kuznetsova et al.
Bulletin of experimental biology and medicine, 142(5), 594-597 (2007-04-07)
A dose-dependent the effect of 5HT2C-receptor agonist MK-212 on mouse behavior was demonstrated. Intraperitoneal injection of MK-212 in high doses (0.5 and 1.0 mg/kg) increased blood level of corticosterone in mice and reduced their motor activity. In low doses of
Peter Salchner et al.
Psychopharmacology, 185(3), 282-288 (2006-03-08)
We have recently reported that acute treatment with the selective serotonin reuptake inhibitor fluoxetine exacerbates escape responses to airjet and facilitates airjet-induced activation of locus coeruleus (LC) neurons. Here we aimed to identify the 5-HT receptor subtype(s) mediating the anxiogenic-like
N K Popova et al.
Neuroscience and behavioral physiology, 40(4), 357-361 (2010-03-26)
The functional activity of serotonin 5-HT(2A) and 5-HT(2C) receptors and the expression of the genes encoding them were studied in Norway rats bred for 60 generations for the presence and absence of high levels of stress-evoked aggression to humans. There
Antonio Pedro de Mello Cruz et al.
Psychopharmacology, 182(3), 345-354 (2005-09-01)
Although 5-HT2 receptors seem to play an important role in anxiety, results from numerous studies are still highly variable. Moreover, little is known about the behavioral effects of centrally administered 5-HT2 compounds in animal models of anxiety. The current study
View All Related Papers

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