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Key Documents

H8636

Sigma-Aldrich

Anti-Haptoglobin antibody produced in rabbit

IgG fraction of antiserum, lyophilized powder

Synonym(s):

Anti-BP, Anti-HP2ALPHA2, Anti-HPA1S

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.46

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

packaging

vial of 2 mL lyophilized antiserum

technique(s)

indirect ELISA: 1:30,000

UniProt accession no.

application(s)

research pathology

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... HP(3240)

General description

Haptoglobin (HP) is encoded by the gene mapped to human chromosome 16q22.2. There are two splice variants of the gene namely, HP1 and HP2.

Immunogen

Human haptoglobin

Application

Anti-Haptoglobin antibody is suitable for use in Ouchterlony double diffusion (1:16) and immunoelectrophoresis.
Anti-Haptoglobin antibody produced in rabbit has been used in immunohistochemistry and western blotting.

Biochem/physiol Actions

Haptoglobin is an antioxidant protein that binds with hemoglobin. Haptoglobin primarily functions to inhibit oxidative damage induced by hemoglobin. Alterations in haptoglobin have been associated with the risk of diabetic vascular disorders such as retinopathy, nephropathy and cardiovascular diseases . Anti-Haptoglobin antibody is specific for haptoglobin in humans.

Physical form

Lyophilized from 0.01 M phosphate buffered saline, pH 7.2

Reconstitution

Reconstitute with 2 ml deionized water.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Vivekananda Shetty et al.
Clinical proteomics, 9(1), 10-10 (2012-08-04)
In approximately 80% of patients, ovarian cancer is diagnosed when the patient is already in the advanced stages of the disease. CA125 is currently used as the marker for ovarian cancer; however, it lacks specificity and sensitivity for detecting early
Diminished acute phase response and increased hepatic inflammation of aged rats in response to intraperitoneal injection of lipopolysaccharide
Gomez C, et al.
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 63(12), 1299-1306 (2008)
Haptoglobin 2 allele associates with unstable carotid plaque and major cardiovascular events
Ijas P, et al.
Atherosclerosis, 230(2), 228-234 (2013)
Hagit Goldenstein et al.
Pharmacological research, 66(1), 1-6 (2012-04-03)
Haptoglobin (Hp) is a hemoglobin (Hb) binding protein whose major function is to prevent heme-iron mediated oxidation. The polymorphic nature of the Hp gene results in varying levels of antioxidant function associated with the protein products. Multiple clinical studies have
Farid M Nakhoul et al.
Nature clinical practice. Nephrology, 3(6), 339-344 (2007-05-26)
Vascular complications cause serious morbidity in patients with diabetes mellitus. Three such complications are nephropathy, retinopathy and accelerated atherosclerotic cardiovascular disease. There is currently scant evidence of a genetic marker that predicts which patients will have vascular complications. Oxidative stress

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