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Sigma-Aldrich

Adenosine 5′-triphosphate (ATP) disodium salt hydrate

vial of ~1 mg ATP

Synonym(s):

ATP disodium hydrate

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About This Item

Linear Formula:
C10H14N5O13P3Na2 · xH2O
CAS Number:
Molecular Weight:
551.14 (anhydrous basis)
EC Number:
MDL number:
UNSPSC Code:
12352202
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.26

biological source

bacterial (Corynebacterium sp)

Quality Level

Assay

≥90%

form

lyophilized powder

packaging

vial of ~1 mg ATP

storage temp.

−20°C

SMILES string

Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O

InChI

1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1

InChI key

NTBQNWBHIXNPRU-MSQVLRTGSA-L

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Application

Adenosine 5′-triphosphate (ATP) disodium salt hydrate has been:
  • used as a standard to measure ATP by bioluminescence method
  • used in kinase buffer to assess the interaction between death-associated protein kinases (DAPK2) and 14-3-3-β
  • used as a standard in ATP colorimetric assay

Biochem/physiol Actions

Adenosine 5′-triphosphate (ATP) is one of the nucleoside triphosphate present in living system. It controls various biologic processes such as glucose metabolism, muscle contraction and neurotransmission. Apart from this, ATP serves as an important energy source for the cell. Administration of ATP might be useful in the treatment of non-small-cell lung cancer.
Adenosine 5′-triphosphate was shown to have inhibitory effects on the inflammatory response by abrogating secretion of TNF-α and promoting secretion of Interleukin-10.
P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; substrate for ATP-dependent enzyme systems

Quantity

Each vial contains ~1.2 mg of Na2ATP • 3H2O equivalent to ~1.0 mg of ATP (2.0 μmol). Actual amount printed on the label.

Preparation Note

Prepared to be substantially vanadium-free.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Chavez-Valdez R, et al.
Neuroscience, 219, 192-203 (2012)
Els L R Swennen et al.
European journal of immunology, 35(3), 852-858 (2005-02-19)
In vitro studies suggest that extracellular nucleotides and nucleosides may be important regulators of inflammatory and immune responses. Most studies with adenosine 5'-triphosphate (ATP) have been performed in cell lines, which are remote from the human situation. The purpose of
Andrei A Ivanov et al.
Journal of medicinal chemistry, 50(6), 1166-1176 (2007-02-17)
A rhodopsin-based homology model of the nucleotide-activated human P2Y2 receptor, including loops, termini, and phospholipids, was optimized with the Monte Carlo multiple minimum conformational search routine. Docked uridine 5'-triphosphate (UTP) formed a nucleobase pi-pi complex with conserved Phe3.32. Selectivity-enhancing 2'-amino-2'-deoxy
Identification of novel death-associated protein kinase 2 interaction partners by proteomic screening coupled with bimolecular fluorescence complementation
Geering B, et al.
Molecular and Cellular Biology, 36(1), 132-143 (2016)
Jie Ge et al.
Journal of medicinal chemistry, 49(15), 4606-4615 (2006-07-21)
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