Skip to Content
Merck
All Photos(3)

Documents

D8040

Sigma-Aldrich

(±)-trans-U-50488 methanesulfonate salt

Synonym(s):

trans-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide methanesulfonate salt, U-50488H

Sign Into View Organizational & Contract Pricing
All Photos(3)

About This Item

Empirical Formula (Hill Notation):
C19H26Cl2N2O · CH4O3S
Molecular Weight:
465.43
MDL number:
MFCD00133867
UNSPSC Code:
12352106
PubChem Substance ID:
24278070
NACRES:
NA.77

form

powder

Quality Level

200

solubility

H2O: 50 mg/mL

storage temp.

2-8°C

SMILES string

CS(O)(=O)=O.CN([C@@H]1CCCC[C@H]1N2CCCC2)C(=O)Cc3ccc(Cl)c(Cl)c3

InChI

1S/C19H26Cl2N2O.CH4O3S/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23;1-5(2,3)4/h8-9,12,17-18H,2-7,10-11,13H2,1H3;1H3,(H,2,3,4)/t17-,18-;/m1./s1

InChI key

OJPHNZCUXUUVKU-JAXOOIEVSA-N

Gene Information

human ... OPRK1(4986)

Application

(±)-trans-U-50488 methanesulfonate salt has been used as a control agonist for κ-opioid receptor.

Biochem/physiol Actions

Selective κ-opioid receptor agonist. (±)-trans-U-50488 methanesulfonate salt is known to induce diuresis. U-50488H is found to prevent morphine tolerance when administered along with it.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Opioid receptor delta as a global modulator of skin differentiation and barrier function repair
Chajra H, et al.
International Journal of Cosmetic Science, 37(4), 386-394 (2015)
Guang-Jie Gao et al.
Evidence-based complementary and alternative medicine : eCAM, 2022, 2868135-2868135 (2022-08-30)
Acute lung injury (ALI) is one of the common and severe complications of cardiopulmonary bypass (CPB), which is the primary cause of death in intensive care units. Nevertheless, there is a lack of effective treatment for ALI secondary to CPB.
Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats
Beardsley PM, et al.
Psychopharmacology, 183(1), 118-118 (2005)
Pharmacology and Therapeutics in the New Millennium, 462-462 (2001)
Unique behavioural phenotypes of recombinant-inbred CXBK mice: partial deficiency of sensitivity to μ- and κ-agonists.
Ikeda, K., et al.
Journal of Neuroscience Research, 34, 149-155 (1999)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service