D4641

n-Dodecyl β-D-maltoside

≥98% (GC)

• Synonym(s): DDM, Lauryl-β-D-maltoside
• Empirical Formula (Hill Notation): C₂₄H₄₆O₁₁
• CAS Number: 69227-93-6
• Molecular Weight: 510.62
• Beilstein: 55318
• MDL number: MFCD00043012
• UNSPSC Code: 12161900
• eCl@ss: 32190102
• PubChem Substance ID: 24893890
• NACRES: NA.25

Properties

• biological source: corn
• Quality Level: 200
• description: non-ionic
• Assay: ≥98% (GC)
• form: powder
• mol wt: micellar avg mol wt 50,000
• aggregation number: 98
• technique(s): protein quantification: suitable
• impurities: <1.5% water (Karl Fischer)
• CMC: 0.15 mM (20-25°C)
• mp: 224-226 °C (lit.)
• solubility: water: 50 mg/mL, clear to very slightly hazy, colorless
• storage temp.: −20°C
• SMILES string: CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O
• InChI: 1S/C24H46O11/c1-2-3-4-5-6-7-8-9-10-11-12-32-23-21(31)19(29)22(16(14-26)34-23)35-24-20(30)18(28)17(27)15(13-25)33-24/h15-31H,2-14H2,1H3/t15-,16-,17-,18+,19-,20-,21-,22-,23-,24-/m1/s1
• InChI key: NLEBIOOXCVAHBD-QKMCSOCLSA-N

Description

General description

N-dodecyl-β-D-maltoside, also known as Lauryl Maltoside, stands as a non-ionic surfactant and derivative of pyrene (Py). Functioning as an alkyl maltopyranoside detergent, it excels particularly in the solubilization and crystallization of membrane proteins, making it a crucial tool in cell biology and biochemical research. Its unique capability arises from its adeptness at forming micelles that mimic the membrane environment, thereby preserving the α-helical structures and native conformations of membrane-associated proteins.

In addition to its primary function, N-dodecyl-β-D-maltoside has diverse applications, including the purification and stabilization of RNA polymerase, the detection of protein-lipid interactions, and serving as a substrate for glucosyl and xylosyl transfer by glycogenin. Its mild and non-denaturing properties have further led to its utilization in protein-anesthetic studies. Overall, N-dodecyl-β-D-maltoside emerges as a versatile detergent with a broad range of applications in membrane protein research and beyond. Its pivotal role in preserving protein structure and function establishes it as an indispensable tool for exploring the intricacies of membrane biology.

Application

Non-ionic detergent for the stabilization and activation of enzymes and for membrane research.

Non-ionic detergent used to extract and solubilize proteins.

n-Dodecyl β-D-maltoside has been used in a study to assess the mapping of unfolding states of integral helical membrane proteins by GPS-NMR and scattering techniques. [1]

Features and Benefits

• Highly versatile surfactant for your cell biology and biochemical research
• Suitable for protein quantification

Other Notes

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Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves