C2374

Cyclo-Gly-Pro

≥98% (GC/HPLC)

• Synonym(s): (S)-3,6-Dioxohexahydropyrrolo[1,2-a]pyrazine, Glycyl-L-proline lactam, cyclo-GP, cyclo-Glycyl-L-Proline, cyclo-L-prolylglycine
• Empirical Formula (Hill Notation): C₇H₁₀N₂O₂
• CAS Number: 3705-27-9
• Molecular Weight: 154.17
• MDL number: MFCD01083707
• UNSPSC Code: 12352200
• PubChem Substance ID: 329774997
• NACRES: NA.32

Properties

• Assay: ≥98% (GC/HPLC)
• form: powder
• solubility: DMSO: >10 mg/mL
• storage temp.: −20°C
• SMILES string: O=C1CNC(=O)C2CCCN12
• InChI: 1S/C7H10N2O2/c10-6-4-8-7(11)5-2-1-3-9(5)6/h5H,1-4H2,(H,8,11)
• InChI key: OWOHLURDBZHNGG-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Cyclo-Gly-Pro is a neuro-protective compound, an endogenous diketopiperazine, which enhances memory. In the animal model of PD, the compound improved functional recovery when administered after the onset of dyskinesia. It appears that the compound recovery function may result from non-proliferative neurogenesis that results from the inhibition of apoptosis of stem cells and/or the promotion of neuronal-orientated proliferation in the SVZ (subventricular zone).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable