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01973

Supelco

4-Aminobenzoic acid

analytical standard

Synonym(s):

PABA, Vitamin Bx, Vitamin H1

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About This Item

Linear Formula:
H2NC6H4CO2H
CAS Number:
Molecular Weight:
137.14
Beilstein:
471605
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

Assay

≥98.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

186-188 °C
187-189 °C (lit.)

density

1.374 g/mL at 25 °C (lit.)

application(s)

cleaning products
cosmetics
environmental
food and beverages
personal care

format

neat

SMILES string

Nc1ccc(cc1)C(O)=O

InChI

1S/C7H7NO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,8H2,(H,9,10)

InChI key

ALYNCZNDIQEVRV-UHFFFAOYSA-N

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Application


  • 4-Aminobenzoic Acid (PABA) in Pharmaceutical Development: Recognized as a valuable biochemical research reagent, 4-aminobenzoic acid is extensively used in the synthesis of various pharmaceutical compounds. Its role as a building block in drug design is crucial for developing new therapeutic agents, particularly in the fields of dermatology and oncology (Clegg and Nichol, 2024).

  • UV Protection Research: PABA is renowned for its UV-absorbing properties, making it a key ingredient in sunscreen formulations. Ongoing research evaluates its efficacy and safety, ensuring optimal protection against UV radiation and its potential role in preventing skin cancer (Wang et al., 2024).

  • Enzyme Inhibitor Studies: As a nucleoside enzyme inhibitor, 4-aminobenzoic acid is pivotal in biochemical studies that explore the inhibition mechanisms of specific enzymes. These studies are fundamental for understanding disease pathways and developing enzyme-targeted therapies (Buch et al., 2024).

  • Vitamin B10 Research: Also known as Vitamin B10, PABA is studied for its role in human nutrition and its therapeutic effects, including in the management of fibrotic skin disorders and hair growth promotion. Research continues to uncover the broader health benefits of this compound (Berto et al., 2024).

  • High-Purity PABA for Laboratory Applications: In scientific research, high-purity 4-aminobenzoic acid is essential for conducting precise and controlled experiments, particularly in studies related to its pharmacological properties and its interaction with other biochemical substances in the body (Park et al., 2024).

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Ion Mobility: TWCCSN2 value of 133.2 Å2 [M+H]+

The collision cross section (CCS) measurement was provided by Waters Corporation, using the SYNAPT XS mass spectrometer.
For a description and overview of how ion mobility enables the measurement of the CCS of an ion visit ims.waters.com.
Further information on the SYNAPT XS mass spectrometer can be found on the IMS microsite and product webpage.

TWCCS measurements are expected to be within 2% of this reference value.

P/N 01973 is part of the Waters Extractables & Leachables UNIFI scientific library which can be downloaded from Waters Marketplace.

Hazard Statements

Precautionary Statements

Hazard Classifications

Aquatic Chronic 3

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

339.8 °F - closed cup

Flash Point(C)

171 °C - closed cup


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P G Lankisch et al.
Gastroenterology, 90(2), 350-354 (1986-02-01)
Serum fluorescein and p-aminobenzoic acid were measured during a urine pancreolauryl and an N-benzoyl-l-tyrosyl-p-aminobenzoic acid (NBT-PABA) test in 22 healthy controls, 17 patients with gastrointestinal nonpancreatic diseases (normal secretin-pancreozymin test), and 31 patients with abnormal exocrine pancreatic function due to
Lei Zhou et al.
Water research, 47(1), 153-162 (2012-10-23)
Dissolved organic matter (DOM) is an important photosensitizer for the phototransformation of organic contaminants in sunlit natural waters. This article focuses on the photolysis kinetics and mechanism of sunscreen agent p-aminobenzoic acid (PABA) in the presence of four kinds of
L O Derewlany et al.
The Journal of pharmacology and experimental therapeutics, 269(2), 756-760 (1994-05-01)
The fetus is exposed to almost all of the substances found in the maternal circulation whether nutrients or foreign chemicals ("xenobiotics"). The main route of exposure is the placenta. The placenta is metabolically active toward xenobiotics and the nature of
L O Derewlany et al.
The Journal of pharmacology and experimental therapeutics, 269(2), 761-765 (1994-05-01)
Studies in our laboratory have shown that the N-acetylation activity of the human term placenta is a predominantly attributable to the NAT1 form of arylamine N-acetyltransferase (NAT). To further assess the acetylation capacity of the placenta, the N-acetylation of the
Shu-Ting Chen et al.
Journal of the American Society for Mass Spectrometry, 23(8), 1408-1418 (2012-06-08)
A strategy based on negative ion electrospray ionization tandem mass spectrometry and closed-ring labeling with both 8-aminopyrene-1,3,6-trisulfonate (APTS) and p-aminobenzoic acid ethyl ester (ABEE) was developed for linkage and branch determination of high-mannose oligosaccharides. X-type cross-ring fragment ions obtained from

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