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MAB427

Sigma-Aldrich

Anti-Dihydropyridine-sensitive Calcium Channel α 1 Subunit Antibody, clone 1a

ascites fluid, clone mAB 1a, Chemicon®

Synonym(s):

Anti-CACNL1A3, Anti-CCHL1A3, Anti-Cav1.1, Anti-HOKPP, Anti-HOKPP1, Anti-MHS5, Anti-TTPP1, Anti-hypoPP

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

ascites fluid

antibody product type

primary antibodies

clone

mAB 1a, monoclonal

species reactivity

rabbit, mouse, human, rat

manufacturer/tradename

Chemicon®

technique(s)

flow cytometry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_000069.2

UniProt accession no.

Q13698

shipped in

dry ice

target post-translational modification

unmodified

Specificity

Dihydropyridine calcium channel, a1 subunit as determined by Western blot (~210 kDa), immunoprecipitation and functional test. Membrane preparations are recommended. The mouse muscle cell line, BC3H1 functions as a good positive control cell line. Reactive with L-type calcium channel alpha1 subunit. Specific for small cell carcinoma and neuroblastoma by FACS analysis. No interaction with squamous cell carcinoma or with cardiac calcium chanel isoforms.

Application

Anti-Dihydropyridine-sensitive Calcium Channel α 1 Subunit Antibody, clone 1a is an antibody against Dihydropyridine-sensitive Calcium Channel α 1 Subunit for use in FC, IP & WB.
Western blot, immunoprecipitation and FACS.

Optimal working dilutions must be determined by end user.

Linkage

Replaces: 06-422

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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T Szikra et al.
Neuroscience, 141(1), 143-155 (2006-05-10)
Vertebrate photoreceptors consist of strictly delimited subcellular domains: the outer segment, ellipsoid, cell body and synaptic terminal, each hosting crucial cellular functions, including phototransduction, oxidative metabolism, gene expression and transmitter release. We used optical imaging to explore the spatiotemporal dynamics
Nazarul Hasan et al.
Visual neuroscience, 33, E009-E009 (2016-07-30)
Cacna1s encodes the α1S subunit (Cav1.1) of voltage-dependent calcium channels, and is required for normal skeletal and cardiac muscle function, where it couples with the ryanodine receptor to regulate muscle contraction. Recently CACNA1S was reported to be expressed on the
Ryutaro Akiba et al.
Frontiers in cellular neuroscience, 13, 16-16 (2019-02-26)
Quantitative and qualitative evaluation of synapses is crucial to understand neural connectivity. This is particularly relevant now, in view of the recent advances in regenerative biology and medicine. There is an urgent need to evaluate synapses to access the extent
Localization of Cacna1s to ON bipolar dendritic tips requires mGluR6-related cascade elements.
Tummala, SR; Neinstein, A; Fina, ME; Dhingra, A; Vardi, N
Investigative Ophthalmology & Visual Science null
R G Parton et al.
The Journal of cell biology, 136(1), 137-154 (1997-01-13)
Caveolae, flask-shaped invaginations of the plasma membrane, are particularly abundant in muscle cells. We have recently cloned a muscle-specific caveolin, termed caveolin-3, which is expressed in differentiated muscle cells. Specific antibodies to caveolin-3 were generated and used to characterize the
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