Aldehydes, 1,3-indandione and cyclohexylisocyanide undergo smooth coupling-cyclization in water to produce the corresponding 2-(cyclohexylamino)-3-aryl- indeno [1,2-b] furan-4-ones in good yields. Water was used as a solvent to avoid the use of other highly toxic and environmentally unfavorable solvents for this
[Effect of S-oxidation on the anticoagulant effects of 4-hydroxycoumarins, 4-hydroxy-2-pyrones and 1,3-indanediones].
K Rehse et al.
Archiv der Pharmazie, 317(3), 262-267 (1984-03-01)
Current study deals with the evaluation of indane-1,3-dione based compounds as new class of urease inhibitors. For that purpose, benzylidine indane-1,3-diones (1-30) were synthesized and fully characterized by different spectroscopic techniques including EI-MS, HREI-MS, 1H, and 13C NMR. All synthetic
Journal of medicinal chemistry, 28(11), 1591-1596 (1985-11-01)
A series of 2-substituted indan-1,3-dione derivatives, including alkyl (C-1-C-5), mono- and disubstituted phenyl, and other 2-aryl derivatives, were tested for hypolipidemic activity of CF1 male mice at 20 mg/kg per day. These derivatives reduced both serum cholesterol and triglycerides after
Chemical & pharmaceutical bulletin, 54(10), 1391-1396 (2006-10-04)
This is an environmentally friendly method in the field of electroorganic reactions under controlled potential electrolysis, without toxic reagents at a carbon electrode in an undivided cell which involves the (EC) mechanism reaction and comprises two steps alternatively; (i) electrochemical
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