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Sigma-Aldrich

Graphene oxide for bioconjugation

6-arm PEG amine functionalized

Synonym(s):

Bioconjugatable graphene oxide

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About This Item

UNSPSC Code:
12352119
NACRES:
NA.23

Quality Level

form

dispersion in H2O

mol wt

PEG Mw 15,000 (6-arm PEG amine)

concentration

2.0 mg/mL

color

dark brown

pH

3-4

General description

Graphene oxide is a hydrophilic two-dimensional (2D) material that is dispersible in water. This graphene oxide product contains covalently bound 6-arm PEG (15K) amine linkers that can be used for bioconjugation with carboxylic acid containing biomolecules. The 6-arm PEG amine functionality increases the number of binding sites for bioconjugation versus graphene oxide, and the amine groups offer popular and established coupling chemistry.

Application

Our bioconjugatable graphene oxide brings the advantages of two-dimensional materials to biotechnology. The fluorescence quenching property of graphene oxide has been used in many biosensor applications. Amine functionalization makes our graphene oxide easy to couple your protein, antibody, or other carboxylic acid containing target for use in biosensor applications based on fluorescence quenching. Additionally, graphene oxide has been used extensively in tissue engineering applications. PEG modification may even increase the biocompatibility of graphene oxide in vivo. Lastly, graphene oxide has been used in targeted drug delivery and in photothermal cancer therapy, and our bioconjugatable graphene oxide makes it easier to add your targeting ligands.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2


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Ana M Díez-Pascual et al.
ACS applied materials & interfaces, 8(28), 17902-17914 (2016-07-08)
Poly(propylene fumarate) (PPF)-based nanocomposites incorporating different amounts of polyethylene glycol-functionalized graphene oxide (PEG-GO) have been prepared via sonication and thermal curing, and their surface morphology, structure, thermal stability, hydrophilicity, water absorption, biodegradation, cytotoxicity, mechanical, viscoelastic and antibacterial properties have been
Graphene Oxide as an Optical Biosensing Platform.
Narvaez M, et al.
Advanced Mat., 24, 3298-3298 (2012)
Functionalized graphene oxide triggers cell cycle checkpoint control through both the ATM and the ATR signaling pathways.
Wang Y, et al.
Carbon, 129, 495-503 (2018)
Zahra Abdollahi et al.
Journal of biotechnology, 298, 88-97 (2019-04-16)
Polymer-coated nanocarriers play an important role in targeted drug delivery. The use of polymers such as polyethylene glycol increases stability, biocompatibility, and blood circulation time of the drug, and may consequently improve the success of drug delivery. In the present
Graphene-based materials for tissue engineering.
Shin S R, et al
Advanced Drug Delivery Reviews, 105, 255-255 (2016)

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