373974

Poly(2-ethyl-2-oxazoline)

average M_w ~500,000, PDI 3‑4

• Synonym(s): PEOX, POx, PetOx, poly 2-ethyloxazoline, polyethyloxazoline
• Linear Formula: [-N(COC₂H₅)CH₂CH₂-]_n
• CAS Number: 25805-17-8
• MDL number: MFCD00134377
• UNSPSC Code: 12162002
• PubChem Substance ID: 329755641
• NACRES: NA.23

Properties

• form: solid
• Quality Level: 200
• mol wt: average M_w ~500,000
• viscosity: 60-80 cSt, 10 % in H₂O
• density: 1.14 g/mL at 25 °C (lit.)
• PDI: 3‑4
• InChI: 1S/C5H9NO/c1-2-5-6-3-4-7-5/h2-4H2,1H3
• InChI key: NYEZZYQZRQDLEH-UHFFFAOYSA-N

Description

Application

This Poly(2-ethyl-2-oxazoline) polymer is amorphous and water soluble with good temperature stability. Jordan and coworkers showed biocompatibility, no accumulation in tissue, and rapid clearance from the bloodstream. End-group modified poly(2-ethyl-2-oxazoline)s have been conjugated to peptides, and were shown as versatile alternatives to poly(ethylene glycol) (PEG) for both protein and small drug conjugation.

Potential substitute for poly(vinyl alcohol) and poly(vinyl pyrrolidone). Adhesion promoter in coatings. Heat sealing and remoistenable hot-melt adhesive

Features and Benefits

Nonionic, water-soluble thermoplastic. Better heat stability than poly(vinyl alcohol). Good melt flow, shear stability and Newtonian characteristics. Water is a room temperature Theta solvent.

Physical form

N-propionyl substituted linear polyethylenimine

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves