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O7635

Sigma-Aldrich

Anti-Osteopontin antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-OPN

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About This Item

MDL number:
MFCD02263865
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

mouse

technique(s)

capture ELISA: 0.2-0.8 μg/mL
immunohistochemistry: 5-15 μg/mL using mouse thymus tissue sections
neutralization: 1-3 μg/mL
western blot: 0.1-0.2 μg/mL

UniProt accession no.

P10923

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Spp1(20750)

General description

The OPN (osteopontin) gene is mapped to mouse chromosome 5 E5 and codes for secreted phosphoprotein 1 and is mostly expressed in bone tissue.

Immunogen

purified recombinant mouse osteopontin expressed in NSO cells.

Biochem/physiol Actions

Osteopontin (OPN) serves as a ligand to a number of integrin receptors which are associated with cell motility, chemotaxis, invasion and cell survival. Upregulation of OPN gene is observed in tumors such as colorectal carcinomas, breast cancer and contributes to its pathogenesis. OPN is associated with obesity by mediating adipocyte inflammation and insulin resistance upon macrophage activation. OPN functions as an effector molecule in extracellular signalling and promotes fibrosis and myocyte growth.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Analysis Note

Neutralizes the biological activity of recombinant mouse osteopontin using 293 cells.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Suppression of osteopontin inhibits chemically induced hepatic carcinogenesis by induction of apoptosis in mice.
Lee S H, et al.
Oncotarget, 7(52), 87219-87219 (2016)
Osteopontin Deficiency Suppresses Intestinal Tumor Development in Apc-Deficient Min Mice.
Ishigamori R, et al.
International Journal of Molecular Sciences, 18(5), 1058-1058 (2017)
Transcriptome analysis of fetal metatarsal long bones by microarray, as a model for endochondral bone formation.
Sugars R V, et al.
Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression, 1763(10), 1031-1039 (2006)
Tracking the embryonic stem cell transition from ground state pluripotency.
Kalkan T, et al.
Development, dev-142711 (2017)
Mio Yamane et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(8), 10778-10800 (2020-07-04)
Chronic graft-vs-host disease (cGVHD) is a multifactorial inflammatory disease that affects patients undergoing hematopoietic stem cell transplantation. Multiple organs, including the lacrimal glands (LGs), are negatively affected by cGVHD and lose function due to the resultant fibrosis. An abnormal immune
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