D3775

Doxylamine succinate salt

• Empirical Formula (Hill Notation): C₁₇H₂₂N₂O · C₄H₆O₄
• CAS Number: 562-10-7
• Molecular Weight: 388.46
• NACRES: NA.77
• PubChem Substance ID: 24278368
• UNSPSC Code: 12352116
• EC Number: 209-228-7
• MDL number: MFCD00056168
• Form: powder

Properties

• form: powder
• Quality Segment: 200
• originator: Sanofi Aventis
• SMILES string: OC(=O)CCC(O)=O.CN(C)CCOC(C)(c1ccccc1)c2ccccn2
• InChI: 1S/C17H22N2O.C4H6O4/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16;5-3(6)1-2-4(7)8/h4-12H,13-14H2,1-3H3;1-2H2,(H,5,6)(H,7,8)
• InChI key: KBAUFVUYFNWQFM-UHFFFAOYSA-N
• Gene Information: human ... HRH1(3269)

Description

General description

Doxylamine belongs to the ethanolaime class of antihistamines and is metabolized by the liver into N-demethyl doxylamine and N,N-didemethyl doxylamine.[1] It is generally available as an over the counter (OTC) drug for allergy and cold symptoms.[2]

Application

Doxylamine succinate salt has been used as a therapeutic drug to check developmental toxicity.[3]

Doxylamine succinate salt has been used to study the effects of non-teratogenic exposures on morphology and gene expression in human embryonic stem cell aggregates (HESCA)-CSR, under low concentration of retinoic acid in CS medium.[4]

Biochem/physiol Actions

H₁ histamine receptor antagonist; hypnotic.
Doxylamine suppresses histamine at the H1 receptor.[1] It is associated with the short term management of insomnia and temporary relief of common cold symptoms. On the other hand, doxylamine intoxication is linked with rhabdomyolysis and secondary acute renal failure.[5]
Studies in mice show that doxylamine induces liver microsomal cytochrome P450 and other enzymes involved in thyroxine (T4) metabolism.[2] In combination with pyridoxine hydrochloride, this drug is used to treat morning sickness.

Features and Benefits

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302 + H312 + H332,H335
• pcodes: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk: WGK 2
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves