D1306
Debrisoquine sulfate
powder, ≥98% (TLC)
Synonym(s):
3,4-Dihydro-2(1H)-isoquinolinecarboximidamide, Debrisoquin sulfate, Ro 5-33071
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About This Item
Linear Formula:
C20H26N6 · H2SO4
CAS Number:
Molecular Weight:
448.54
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352204
EC Number:
209-472-4
MDL number:
Product Name
Debrisoquine sulfate,
assay
≥98% (TLC)
Quality Level
form
powder
mp
285 °C
solubility
H2O: 20 mg/mL (with heat)
storage temp.
room temp
SMILES string
OS(O)(=O)=O.NC(=N)N1CCc2ccccc2C1.NC(=N)N3CCc4ccccc4C3
InChI
1S/2C10H13N3.H2O4S/c2*11-10(12)13-6-5-8-3-1-2-4-9(8)7-13;1-5(2,3)4/h2*1-4H,5-7H2,(H3,11,12);(H2,1,2,3,4)
InChI key
CAYGYVYWRIHZCQ-UHFFFAOYSA-N
Gene Information
human ... SLC6A2(6530)
General description
A substrate for cytochrome P450 CYP2D6; an indicator for genetic polymorphism in cytochrome P450.
Biochem/physiol Actions
Debrisoquine is an anti-hypertensive agent. It is metabolized by cytochrome P4502D6.
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signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Ping-Ching Hsu et al.
Molecular carcinogenesis, 56(2), 594-606 (2016-06-25)
Smoking-related biomarkers for lung cancer and other diseases are needed to enhance early detection strategies and to provide a science base for tobacco product regulation. An untargeted metabolomics approach by ultra-performance liquid chromatography-quadrupole-time of flight mass spectrometry (UHPLC-Q-TOF MS) totaling
The debrisoquine metabolic phenotype and DNA-based assays: implications of misclassification for the association of lung cancer and the debrisoquine metabolic phenotype.
Caporaso N E, et al.
Environmental Health Perspectives, 98, 101-105 (1992)
E Scarr et al.
Progress in neuro-psychopharmacology & biological psychiatry, 15(2), 297-301 (1991-01-01)
1. Studies were carried out on three monoamine oxidase (MAO) inhibitors, two of which, debrisoquine and para- hydroxyphenelzine, are purported to be peripheral inhibitors and one, phenelzine, is a peripherally acting inhibitor, which has been included for comparitive purposes. 2.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D1306-100MG | 04061833559345 |