C5813
Complement factor H from human plasma
1 mg/mL in PBS, pH 7.2, ≥90% (SDS-PAGE)
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About This Item
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Application
Complement factor H (CFH) is a plasma regulator of the complement protein C3b in the alternative pathway of the complement system. Research has shown that binding of CFH is important for pathogenesis of group A streptococcus (GAS), and inhibition of this binding may be an effective management of GAS infections.
Biochem/physiol Actions
Complement factor H plays an essential role in the homeostasis of the complement system and in preventing collateral damage to bystander cells and tissues by complement activation.
C3b-binding protein which regulates the formation and function of complement C3 and C5 convertases.
Other Notes
View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Storage Class Code
10 - Combustible liquids
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Pangburn, M.K. and muller-Eberhard, H.J.
Springer Semin. Immunopath., 7, 63-63 (1984)
Ruodan Nan et al.
The Journal of biological chemistry, 288(26), 19197-19210 (2013-05-11)
The sub-retinal pigment epithelial deposits that are a hallmark of age-related macular degeneration contain both C3b and millimolar levels of zinc. C3 is the central protein of complement, whereas C3u is formed by the spontaneous hydrolysis of the thioester bridge
Arife Uslu-Gökceoğlu et al.
The Turkish journal of pediatrics, 55(1), 86-89 (2013-05-23)
Atypical hemolytic uremic syndrome (aHUS) is a disease caused by pathologies in the alternative complement system. The prevalence of aHUS is 10% of all aHUS cases. The subgroup of aHUS designated as DEAP (DEficiency of CFHR Proteins and CFH Autoantibody
Katy Vaillancourt et al.
Journal of medical microbiology, 62(Pt 7), 1073-1080 (2013-04-27)
Streptococcus suis is a major swine pathogen and an emerging zoonotic agent. The ability of pathogenic bacteria to bind the complement regulator factor H on their cell surface may allow them to avoid complement attack and phagocytosis. The aim of
D T Fearon et al.
Proceedings of the National Academy of Sciences of the United States of America, 74(4), 1683-1687 (1977-04-01)
The surface of zymosan (Zy), by affording a protected microenvironment for C3b and the amplification convertase stabilized by properdin, P,C3b,Bb, shifts the alternative complement pathway from slow fluid phase turnover to the amplification phase of its expression. This mode of
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