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A5585

5-(N-Methyl-N-isobutyl)­amiloride

≥98% (TLC), powder

Synonym(s):

MIA

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About This Item

Empirical Formula (Hill Notation):
C11H18ClN7O
CAS Number:
96861-65-3
Molecular Weight:
299.76
NACRES:
NA.77
PubChem Substance ID:
24278228
UNSPSC Code:
12352200
MDL number:
MFCD00078567
Assay:
≥98% (TLC)
Form:
powder
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Quality Segment

200

assay

≥98% (TLC)

form

powder

mp

200-201 °C

solubility

methanol: 9.80-10.20 mg/mL, clear, pale yellow to yellow

storage temp.

2-8°C

SMILES string

CC(C)CN(C)c1nc(N)c(nc1Cl)C(=O)NC(N)=N

InChI

1S/C11H18ClN7O/c1-5(2)4-19(3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)

InChI key

RVIUMPLAOXSSGN-UHFFFAOYSA-N

Gene Information

human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768)

Application

5-(N-Methyl-N-isobutyl)­amiloride is a potent blocker of the Na2/H+ antiport. 5-(N-Methyl-N-isobutyl)­amiloride has been used to study early cellular response to acidosis.

Biochem/physiol Actions

Potent blocker of the Na+/H+ antiport. Possible antitumor agent.

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This Item
A3085T3146D2926
5-(N-Methyl-N-isobutyl)­amiloride ≥98% (TLC), powder

Sigma-Aldrich

A5585

5-(N-Methyl-N-isobutyl)­amiloride

5-(N-Ethyl-N-isopropyl)amiloride

Sigma-Aldrich

A3085

5-(N-Ethyl-N-isopropyl)amiloride

Trimipramine maleate salt ≥98% (TLC), powder

Sigma-Aldrich

T3146

Trimipramine maleate salt

Diphenyleneiodonium chloride ≥98%

Sigma-Aldrich

D2926

Diphenyleneiodonium chloride

assay

≥98% (TLC)

assay

≥98% (TLC)

assay

≥98% (TLC)

assay

≥98%

form

powder

form

powder

form

powder

form

powder

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

solubility

methanol: 9.80-10.20 mg/mL, clear, pale yellow to yellow

solubility

methanol: 9.80-10.20 mg/mL, clear, light yellow to yellow

solubility

chloroform: soluble 50 mg/ml, clear, colorless to faintly yellow

solubility

DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow

Gene Information

human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768)

Gene Information

human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548), SLC9A5(6553)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782), Slc9a2(24783), Slc9a3(24784), Slc9a4(24785)

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)

Gene Information

human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)
mouse ... Pik3r1(18708)

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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