A5222
D-Amino Acid Oxidase from porcine kidney
powder, ≥1.5 units/mg solid
Synonym(s):
D-AAO, D-Amino acid: oxygen oxidoreductase (deaminating)
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Application
D-amino acid oxidase (DAO) is a potential target molecule for the treatment of chronic pain and schizophrenia . D-amino acid oxidase is used to oxidize D-amino acids to their corresponding imino acids.
Unit Definition
One unit will oxidatively deaminate 1.0 μmole of D-alanine to pyruvate per minute at pH 8.3 at 25 °C, in the presence of a catalase.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Nature communications, 4, 1366-1366 (2013-01-24)
In eukaryotes, hydrogen sulphide acts as a signalling molecule and cytoprotectant. Hydrogen sulphide is known to be produced from L-cysteine by cystathionine β-synthase, cystathionine γ-lyase and 3-mercaptopyruvate sulfurtransferase coupled with cysteine aminotransferase. Here we report an additional biosynthetic pathway for
Amino acids, 43(5), 1905-1918 (2012-09-22)
D-Amino acid oxidase (DAAO), a FAD-dependent peroxisomal flavoenzyme that catalyzes oxidation of D-amino acids to hydrogen peroxide, is distributed in the spinal cord almost exclusively expressed within astrocytes. The present study aims to explore potential contributions of spinal DAAO to
Methods in molecular biology (Clifton, N.J.), 1887, 23-31 (2018-12-07)
Fermented foods produced using edible microorganisms have been consumed worldwide since ancient times. Microorganisms produce some healthy functional substances. Recently, many people have been attracted to the notion that D-body amino acids have healthy functional effects. D-body amino acids convert
Journal of psychopharmacology (Oxford, England), 24(7), 1055-1067 (2009-03-31)
D-Amino acid oxidase (DAO) has been established to be involved in the oxidation of D-serine, an allosteric activator of the N-methyl-D-aspartate-type glutamate receptor in the brain, and to be associated with the onset of schizophrenia. The effect of risperidone, a
Enzyme and microbial technology, 52(1), 13-19 (2012-12-04)
Oligolamellar phospholipid vesicles incorporated with d-amino acid oxidase from porcine kidney (OV-DAO) were prepared by encapsulating pre-formed enzyme-bound unilamellar vesicles (UV-DAO) with bilayers of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC). The bilayer of UV-DAO was composed of POPC, 30 mol% of cholesterol and 15
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