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MABMAG-83K

Millipore

MILLIPLEX® Mouse Amyloid Beta Magnetic Bead Panel - Multiplex Assay

for quantification of Aβ40 and Aβ42 in mouse serum, plasma, CSF and tissue culture samples

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About This Item

UNSPSC Code:
12161503
eCl@ss:
32161000
NACRES:
NA.47

Quality Level

200

species reactivity

mouse

manufacturer/tradename

Milliplex®

assay range

accuracy: 80%
(Spike recovery for Aβ1-40)
sensitivity: 3.6 pg/mL
(A?1-40; MinDC+2SD)
sensitivity: 4.8 pg/mL
(A?1-42; MinDC+2SD)
standard curve range: 3-2500 pg/mL
(Aβ1-40)
standard curve range: 7-5000 pg/mL
(Aβ1-42)
inter-assay cv: <10%
intra-assay cv: <5%

technique(s)

multiplexing: suitable

detection method

fluorometric (Luminex xMAP)

shipped in

ambient

General description

The MILLIPLEX® Mouse Amyloid Beta Bead Panel enables you to evaluate and quantitate Aβ40 and Aβ42 in your mouse research models. Coupled with the Luminex® xMAP® platform in a bead format, you receive the advantage of ideal speed and sensitivity, allowing quantitative multiplex detection of multiple analytes simultaneously, which can dramatically improve productivity.

The MILLIPLEX® Mouse Amyloid Beta Bead Panel is to be used for the simultaneous quantification of Aβ40 and Aβ42. This kit may be used only for the analysis mouse serum, plasma, cerebrospinal fluid (CSF) and tissue culture samples. This is a configurable assay, and one or both analytes can be selected: amyloid β40, amyloid β42. The MILLIPLEX® portfolio offers the broadest selection of analytes across a wide range of disease states and species. Once the analytes of interest have been identified, you can rely on the quality that we build into each kit to produce results you can trust. In addition to the assay characteristics listed in the protocol, other performance criteria evaluated during the validation process include: cross-reactivity, dilution linearity, kit stability and sample behavior (e.g. detectability and stability). Each panel and kit meets stringent manufacturing criteria to ensure batch-to-batch reproducibility.

Each MILLIPLEX® panel and kit includes:
  • Quality controls (QCs) provided to qualify assay performance
  • Comparison of standard (calibrator) and QC lots to a reference lot to ensure lot-to-lot consistency
  • Optimized serum matrix to mimic native analyte environment
  • Detection antibody cocktails designed to yield consistent analyte profiles within panel MILLIPLEX® Mouse Amyloid Beta Bead Panel is part of the most versatile system available for your research. From our single to multiplex biomarker solutions, we partner with you to design, develop, analytically validate, and build the most comprehensive library available for protein detection and quantitation.

Panel Type: Neuroscience

Specificity

Cross Reactivty
There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes within a panel.

Application

  • Analytes: Amyloid β40, Amyloid β42
  • Recommended Sample type: serum, plasma, cerebrospinal fluid (CSF), and tissue culture
  • Recommended Sample dilution: 1:2 dilution of serum or plasma, 1:10 dilution of cerebrospinal fluid (CSF), or neat/appropriately diluted tissue culture supernatant
  • Assay Run Time:
  • Research Category: Neuroscience Metabolism
  • Research Subcategory: Category Metabolic Disorders Obesity Inflammation & Autoimmune Mechanisms

Features and Benefits

Design your multiplex kit by choosing available analytes within this panel.

Packaging

96-well plate
Everything you need in a single kit.

Components

Mouse ABeta Standard, 1 vial, lyophilized

Mouse ABeta Quality Control 1, 1 vial, lyophilized

Mouse ABeta Quality Control 2, 1 vial, lyophilized

Serum Matrix (0.08% Sodium Azide) 1 vial, lyophilized

Set of one 96-Well Plate with 2 sealers

Assay Buffer, 1 bottle, 30 mL

Wash Buffer, 10X (0.05% Proclin), 1 bottle, 60 mL

Mouse ABeta Detection Antibody, 1 bottle, 3.2 mL

Streptavidin-Phycoerythrin, 1 bottle, 3.2 mL

Mixing Bottle, 1 bottle

Storage and Stability

Recommended storage for kit components is 2 - 8°C.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

Target Organs

Respiratory Tract

Storage Class Code

10 - Combustible liquids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The function and regulation of amyloid-beta (Aβ) in healthy and diseased liver remains unexplored. Because Aβ reduces the integrity of the blood-brain barrier we have examined its potential role in regulating the sinusoidal permeability of normal and cirrhotic liver. Aβ

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