5677

Spermine, Tetrahydrochloride

• Synonym(s): Spermine, Tetrahydrochloride
• Empirical Formula (Hill Notation): C₁₀H₂₆N₄ · 4HCl
• CAS Number: 306-67-2
• Molecular Weight: 348.18
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00012914
• Assay: ≥99% (titration)
• Form: solid
• Storage condition: OK to freeze

Properties

• description: RTECS - EJ7230000; Merck USA index - 14, 8743
• Quality Segment: 100
• assay: ≥99% (titration)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: water: 20 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• SMILES string: [Cl-].[Cl-].[Cl-].[Cl-].[N+H2](CCC[N+H3])CCCC[N+H2]CCC[N+H3]
• InChI: 1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
• InChI key: XLDKUDAXZWHPFH-UHFFFAOYSA-N

Description

General description

Polyamine that plays an important role in the regulation of cellular proliferation and differentiation. Acts as an inhibitor of phopholipase C-α and an activator of phopholipase C-δ. Has both stimulatory and inhibitory effects on NMDA receptors depending on the subunit composition of the receptor. Inhibits neuronal NOS. Inhibits DNA fragmentation and morphological apoptosis.

Biochem/physiol Actions

Primary Target
phospholipase C α

Secondary Target
nNOS

Preparation Note

Following reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C under inert gas.

Other Notes

Igarashi, K. and Williams, K. 1995. J. Pharmacol. Exp. Ther. 272, 1101.
Escargueil-Blanc, I., et al. 1994. FASEB J.8, 1075.
Hu, J., et al. 1994. Neurosci. Lett. 175, 41.
Tompkins, T.A. and Moscarello, M.A. 1994. Biochim. Biophys. Acta1206, 1208.
Trubiani, O., et al. 1994. Biochem. Mol. Biol. Int.32, 1085.
Svensson, F., et al. 1993. Mol. Cell. Biochem.124, 141.
Ask, A., et al. 1992. Cancer Lett.66, 29.
Chida, N., et al. 1992. Brain Res.593, 57.
Khan, A.U., et al. 1992. Proc. Natl. Acad. Sci. USA89, 11428.
Messena, L., et al. 1992. J. Leukoc. Biol. 52, 585.
Pawelczyk, T., et al. 1992. Arch. Biochem. Biophys.297, 328.
Shantz, L.M., et al. 1992. Biochem. J.288, 511.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H315,H319
• Precautionary Statements: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable