C-087

Codeine-6-β-D-glucuronide solution

100 μg/mL in methanol: water (2:8), ampule of 1 mL, certified reference material, Cerilliant^®

• Empirical Formula (Hill Notation): C₂₄H₂₉NO₉
• CAS Number: 20736-11-2
• Molecular Weight: 475.49
• MDL number: MFCD00214264
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• drug control: Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
• concentration: 100 μg/mL in methanol: water (2:8)
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): forensics and toxicology
• format: single component solution
• storage temp.: 2-8°C
• SMILES string: [H][C@]1([C@H](N(C)CC2)C3)[C@@]42C5=C3C=CC(OC)=C5O[C@H]4[C@@H](O[C@@H]6O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]6O)C=C1
• InChI: 1S/C24H29NO9/c1-25-8-7-24-11-4-6-14(32-23-18(28)16(26)17(27)20(34-23)22(29)30)21(24)33-19-13(31-2)5-3-10(15(19)24)9-12(11)25/h3-6,11-12,14,16-18,20-21,23,26-28H,7-9H2,1-2H3,(H,29,30)/t11-,12+,14-,16-,17-,18+,20-,21-,23+,24-/m0/s1
• InChI key: CRWVOYRJXPDBPM-HSCJLHHPSA-N

Description

General description

Codeine-6-β-D-glucuronide is a major urinary metabolite of codeine, an opiate commonly used as an antitussive and analgesic for management of mild pain. This certified reference solution is suitable as starting material for preparation of calibrators and controls in codeine testing by LC/MS or GC/MS for forensic analysis, urine drug testing, or clinical toxicology applications.

Application

• Opiate Metabolite Analysis in Urine: Codeine-6-β-D-glucuronide is utilized in a comprehensive LC-MS/MS analysis to identify opiate metabolites and antihistamines in urine after consumption of cold syrups. This research is crucial for clinical diagnostics and forensic toxicology, providing insights into drug metabolism and potential drug interactions (Yen et al., 2020).


• Quantification of Morphine and Codeine Metabolites: Codeine-6-β-D-glucuronide serves as a key standard in LC-ESI-MS/MS for the quantification of morphine, codeine, and their glucuronide metabolites in human urine. This method is essential for pharmacokinetic studies and therapeutic drug monitoring, enhancing the accuracy of opioid metabolism research (Murphy and Huestis, 2005).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS08,GHS07
• Signal Word: Danger
• Hazard Statements: H226,H302 + H312 + H332,H370
• Precautionary Statements: P210 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P311
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Flam. Liq. 3 - STOT SE 1
• Target Organs: Eyes
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 109.4 °F - closed cup
• Flash Point(C): 43 °C - closed cup