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810195P

Avanti

18:1-12:0 NBD PS

Avanti Research - A Croda Brand 810195P, powder

Synonym(s):

1-oleoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphoserine (ammonium salt)

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About This Item

Empirical Formula (Hill Notation):
C42H73N6O13P
CAS Number:
Molecular Weight:
901.04
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (810195P-1mg)

manufacturer/tradename

Avanti Research - A Croda Brand 810195P

shipped in

dry ice

storage temp.

−20°C

General description

Phosphatidylserine (PS) is an acidic membrane phospholipid present in human cerebral cortex. It is majorly present in the inner leaflet of plasma membrane. NBD PS contains the fluorophore, 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) labelled at the headgroup of PS.

Application

18:1-12:0 NBD PS or 1-oleoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphoserine (ammonium salt), may be used to measure the phosphatidylserine decarboxylase (Psd1) activity.

Biochem/physiol Actions

Phosphatidylserine (PS) is involved in maintaining the nerve cell membrane and myelin sheath. Phosphatidylserine (PS) is associated with Akt, protein kinase C (PKC) and Raf-1 signaling.

Packaging

5 mL Amber Glass Screw Cap Vial (810195P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Phosphatidylserine and the human brain
Glade MJ and Smith K
Nutrition null
Lipid Homeostasis Is Maintained by Dual Targeting of the Mitochondrial PE Biosynthesis Enzyme to the ER
Jonathan R, et al.
Developmental Cell null
Organization and dynamics of N-(7-nitrobenz-2-oxa-1, 3-diazol-4-yl)-labeled lipids: a fluorescence approach
Mukherjee S, et al.
Chemistry and Physics of Lipids null
Structural Basis for Phosphatidylethanolamine Biosynthesis by Bacterial Phosphatidylserine Decarboxylase
Yasunori W, et al.
Structure null
Jonathan R Friedman et al.
Developmental cell, 44(2), 261-270 (2018-01-02)
Spatial organization of phospholipid synthesis in eukaryotes is critical for cellular homeostasis. The synthesis of phosphatidylcholine (PC), the most abundant cellular phospholipid, occurs redundantly via the ER-localized Kennedy pathway and a pathway that traverses the ER and mitochondria via membrane

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