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810132P

Avanti

18:1-06:0 NBD PC

Avanti Research - A Croda Brand

Synonym(s):

1-oleoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphocholine

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About This Item

Empirical Formula (Hill Notation):
C38H64N5O11P
CAS Number:
Molecular Weight:
797.92
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (810132P-1mg)
pkg of 5 × 1 mg (810132P-5mg)
pkg of 5 × 2 mg (810132P-10mg)

manufacturer/tradename

Avanti Research - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

General description

Phosphatidylcholine (PC) is a prime metabolite of glycerolipid metabolism in eukaryotes. It is a vital component of the mucosal layer of the colon and a strong bilayer-forming lipid. NBD PC has 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) moiety attached to phosphatidylcholine.

Application

18:1-06:0 NBD PC is suitable:
  • for the generation of giant unilamellar vesicles (GUVs) subjected to fluorescence microscopy
  • for labeling lipid bilayers formed by vesicle fusion in order to study the lipid distribution by fluorescence microscopy
  • for the preparation of phospholipid-coated beads

Biochem/physiol Actions

7-nitrobenz-2-oxa-1,3-diazol-4-yl phosphatidylcholine (NBD PC) is used as a fluorescent probe in biological membranes to study the cellular processes.

Packaging

5 mL Amber Glass Screw Cap Vial (810132P-10mg)
5 mL Amber Glass Screw Cap Vial (810132P-1mg)
5 mL Amber Glass Screw Cap Vial (810132P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yuta Ryoden et al.
Journal of immunology (Baltimore, Md. : 1950), 204(3), 559-568 (2019-12-22)
In response to extracellular ATP, the purinergic receptor P2X7 mediates various biological processes, including phosphatidylserine (PtdSer) exposure, phospholipid scrambling, dye uptake, ion transport, and IL-1β production. A genome-wide CRISPR screen for molecules responsible for ATP-induced PtdSer exposure identified a transmembrane
Henry A Boumann et al.
Biochimica et biophysica acta, 1788(7), 1444-1451 (2009-04-21)
Anammox bacteria that are capable of anaerobically oxidizing ammonium (anammox) with nitrite to nitrogen gas produce unique membrane phospholipids that comprise hydrocarbon chains with three or five linearly condensed cyclobutane rings. To gain insight into the biophysical properties of these
Wan-Chen Lin et al.
Biophysical journal, 90(1), 228-237 (2005-10-11)
A fundamental attribute of cell membranes is transmembrane asymmetry, specifically the formation of ordered phase domains in one leaflet that are compositionally different from the opposing leaflet of the bilayer. Using model membrane systems, many previous studies have demonstrated the
Sang-Yeob Kim et al.
PloS one, 12(4), e0174603-e0174603 (2017-04-05)
The removal of unwanted or damaged cells by phagocytes is achieved via a finely regulated cleaning process called efferocytosis. To characterize the mechanisms through which phagocytes control the intake of apoptotic cells, we investigated how the phagocyte's appetite for engulfed
Johan Tornmalm et al.
Scientific reports, 9(1), 18133-18133 (2019-12-04)
Protein-lipid interactions in cellular membranes modulate central cellular functions, are often transient in character, but occur too intermittently to be readily observable. We introduce transient state imaging (TRAST), combining sensitive fluorescence detection of fluorophore markers with monitoring of their dark

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