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P4997

Sigma-Aldrich

Anti-Potassium Channel KCa3.1 (Intermediate-conductance Ca2+-activated Potassium Channel 4) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-IKCa1, Anti-KCNN4, Anti-SK4

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About This Item

MDL number:
MFCD06798513
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human, rat, mouse (predicted)

technique(s)

western blot: 1:200

UniProt accession no.

O15554

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KCNN4(3783)
mouse ... Kcnn4(16534)
rat ... Kcnn4(65206)

Immunogen

synthetic peptide corresponding to amino acid residues 350-363 of rat KCa3.1. The sequence has 100% homology with human, mouse, and pig.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Western Blotting (1 paper)

Physical form

Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Valentina Back et al.
Journal of thrombosis and haemostasis : JTH, 20(11), 2587-2600 (2022-07-23)
Within the vasculature platelets and endothelial cells play crucial roles in hemostasis and thrombosis. Platelets, like endothelial cells, possess intermediate conductance Ca2+ -activated K+ (IKCa ) channels and generate nitric oxide (NO). Although NO limits platelet aggregation, the role of
Lee-Way Jin et al.
Annals of clinical and translational neurology, 6(4), 723-738 (2019-04-26)
Microglia play a pivotal role in the initiation and progression of Alzheimer's disease (AD). We here tested the therapeutic hypothesis that the Ca2+-activated potassium channel KCa3.1 constitutes a potential target for treating AD by reducing neuroinflammation. To determine if KCa3.1
Yi-Je Chen et al.
PloS one, 8(11), e81006-e81006 (2013-12-07)
Allograft vasculopathy (AV) remains one of the major challenges to the long-term functioning of solid organ transplants. Although its exact pathogenesis remains unclear, AV is characterized by both fibromuscular proliferation and infiltration of CD4(+) memory T cells. We here tested
Shaun L Sandow et al.
Journal of anatomy, 209(5), 689-698 (2006-10-26)
Activation of endothelial cell small- (S) and intermediate- (I) conductance calcium-activated potassium channels (K(Ca)) and current or molecular transfer via myoendothelial gap junctions underlies endothelium-derived hyperpolarization leading to vasodilation. The mechanism underlying the K(Ca) component of vasodilator activity and the
Eva M Grössinger et al.
Journal of immunology (Baltimore, Md. : 1950), 200(2), 749-757 (2017-12-17)
In inflammatory arthritis, the dysregulation of osteoclast activity by proinflammatory cytokines, including TNF, interferes with bone remodeling during inflammation through Ca2+-dependent mechanisms causing pathological bone loss. Ca2+-dependent CREB/c-fos activation via Ca2+-calmodulin kinase IV (CaMKIV) induces transcriptional regulation of osteoclast-specific genes
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