G5894
Glutaminase from Escherichia coli
Grade VII, lyophilized powder, 500-1,500 units/mg protein
Synonym(s):
L-Glutamine amidohydrolase
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About This Item
CAS Number:
MDL number:
UNSPSC Code:
12352204
NACRES:
NA.54
Recommended Products
type
Grade VII
Quality Level
form
lyophilized powder
specific activity
500-1,500 units/mg protein
composition
Protein, ~10% Lowry
storage temp.
−20°C
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Biochem/physiol Actions
Glutaminase catalyzes the conversion of glutamine to glutamate.
Linkage
Chromatographically purified from Grade V
Unit Definition
One unit will deaminate 1.0 μmole of L-glutamine per min at pH 4.9 at 37 °C.
Physical form
Lyophilized powder containing stabilizer and potassium succinate
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Natalie E Simpson et al.
Epigenetics, 7(12), 1413-1420 (2012-11-03)
The interplay of metabolism and epigenetic regulatory mechanisms has become a focal point for a better understanding of cancer development and progression. In this study, we have acquired data supporting previous observations that demonstrate glutamine metabolism affects histone modifications in
Krupa Shukla et al.
Journal of medicinal chemistry, 55(23), 10551-10563 (2012-11-16)
Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES) is a potent and selective allosteric inhibitor of kidney-type glutaminase (GLS) that has served as a molecular probe to determine the therapeutic potential of GLS inhibition. In an attempt to identify more potent GLS inhibitors with improved
Javier Ampuero et al.
PloS one, 7(11), e49279-e49279 (2012-11-21)
To investigate the influence of metformin use on liver dysfunction and hepatic encephalopathy in a retrospective cohort of diabetic cirrhotic patients. To analyze the impact of metformin on glutaminase activity and ammonia production in vitro. Eighty-two cirrhotic patients with type
Felix List et al.
Chemistry & biology, 19(12), 1589-1599 (2012-12-25)
Nitrogen is incorporated into various metabolites by multifunctional glutamine amidotransferases via reactive ammonia generated by glutaminase hydrolysis of glutamine. Although this process is generally tightly regulated by subsequent synthase activity, little is known about how the glutaminase is inhibited in
N V Zharkova et al.
Biomeditsinskaia khimiia, 58(2), 220-223 (2012-06-26)
Acute alcohol intoxication in rats with alloxan diabetes is accompanied by the increase of urea and uric acid and by the decrease in free fatty acids in serum. In the liver of experimental animals the increase of activity of glutamate
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