D052

GBR 12909 dihydrochloride

solid, ≥98% (HPLC)

• Synonym(s): 1-(2-[bis(4-Fluorophenyl)methoxy]ethyl)-4-(3-phenylpropyl)piperazine dihydrochloride
• Empirical Formula (Hill Notation): C₂₈H₃₂F₂N₂O · 2HCl
• CAS Number: 67469-78-7
• Molecular Weight: 523.49
• MDL number: MFCD00055193
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277909
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• color: white
• solubility: DMSO: >5 mg/mL (Solutions freshly prepared daily)
• SMILES string: Cl.Cl.Fc1ccc(cc1)C(OCCN2CCN(CCCc3ccccc3)CC2)c4ccc(F)cc4
• InChI: 1S/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H
• InChI key: MIBSKSYCRFWIRU-UHFFFAOYSA-N
• Gene Information: human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)

Description

Application

GBR 12909 dihydrochloride has been used as a dopamine transporter (DAT) inhibitor:

• to study its effects on LPS-induced mRNA expression on the proinflammatory cytokines in the mouse striatum
• to study its effects on neurotransmitter release in zebrafish brain
• in DA uptake assay in mice striatal fraction

Biochem/physiol Actions

GBR 12909 may show pharmacotherapeutic effects against cocaine addiction.

GBR 12909 is a highly selective dopamine reuptake inhibitor with behavioral effects similar to cocaine.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves