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M2649

Sigma-Aldrich

Melanin from Sepia officinalis

99% purity (TLC), powder

Synonym(s):

Melanin

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About This Item

CAS Number:
8049-97-6
EC Number:
232-473-6
MDL number:
MFCD00131581
UNSPSC Code:
12171500
NACRES:
NA.47

product name

Melanin from Sepia officinalis, 99% (TLC)

Quality Level

200

Assay

99% (TLC)

form

powder

solubility

hydrogen peroxide: 1 mg/mL, dark brown

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

−20°C

InChI

1S/C18H10N2O4/c1-5-13-9-7(3-19-13)12-10-8(11(9)17(23)15(5)21)4-20-14(10)6(2)16(22)18(12)24/h3-4,19-20H,1-2H3

InChI key

XUMBMVFBXHLACL-UHFFFAOYSA-N

Related Categories

General description

Melanin is a ubiquitous and prominent pigment responsible for color of skin, hair and eyes. Melanin is classified into eumelanin and pheomelanin. Eumelanin is black to dark brown pigment and is present in black hair and retina of the eye. Pheomelanin is yellow to reddish brown pigment present is red hair and red feathers. Melanins are high molecular weight pigments synthesized from phenolic or indolic precursors and is widely present in animals, plants and microorganisms.

Application

Melanin from Sepia officinalis has been used:
  • as a natural pigment for Raman spectroscopy measurements
  • in competitive enzyme linked immunosorbent assay (ELISA) for the characterization of phage antibodies
  • as an external standard for spectrophotometrically determining the melanin production in B16F10 cells

Biochem/physiol Actions

Melanin scavenges active chemical species and acts as a sunscreen.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
103H1023
100H0118
099F0746

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Iwei Yeh et al.
Nature communications, 8(1), 644-644 (2017-09-25)
Deep penetrating nevus (DPN) is characterized by enlarged, pigmented melanocytes that extend through the dermis. DPN can be difficult to distinguish from melanoma but rarely displays aggressive biological behavior. Here, we identify a combination of mutations of the β-catenin and
Melanogenesis in the ink gland of Sepia officinalis.
Palumbo A
Pigment Cell Research / Sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, 16, 517-517 (2003)
Localization of melanin in conidia of Alternaria alternata using phage display antibodies
Carzaniga R, et al.
Molecular plant-microbe interactions : MPMI, 15(3), 216-224 (2002)
Detection of antibodies against Paracoccidioides brasiliensis melanin in in vitro and in vivo studies during infection.
Uran ME
Clinical and Vaccine Immunology : CVI, 18, 1680-1680 (2011)
Chikako Yoshikawa-Murakami et al.
International journal of molecular sciences, 21(22) (2020-11-18)
Melanin incorporated into keratinocytes plays an important role in photoprotection; however, abnormal melanin accumulation causes hyperpigmentary disorders. To understand the mechanism behind the accumulation of excess melanin in the skin, it is essential to clarify the spatial distribution of melanosomes
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