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340855

Sigma-Aldrich

Glutaraldehyde solution

50 wt. % in H2O

Synonym(s):

Glutaric dialdehyde solution, Pentane-1,5-dial

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About This Item

Linear Formula:
OHC(CH2)3CHO
CAS Number:
Molecular Weight:
100.12
Beilstein:
605390
MDL number:
UNSPSC Code:
12352114
PubChem Substance ID:
NACRES:
NA.21

vapor density

1.05 (vs air)

Quality Level

vapor pressure

15 mmHg ( 20 °C)

form

liquid

concentration

50 wt. % in H2O

technique(s)

electron microscopy: suitable
immunoblotting: suitable
immunohistochemistry: suitable

color

colorless

refractive index

n20/D 1.42

mp

-21  °C ((-6 °F))

solubility

water: soluble

density

1.106 g/mL at 25 °C

suitability

suitable for microfluidics/nanofluidics

application(s)

cell analysis
genomic analysis
life science and biopharma
sample preparation

SMILES string

[H]C(CCCC([H])=O)=O

InChI

1S/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2

InChI key

SXRSQZLOMIGNAQ-UHFFFAOYSA-N

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General description

Glutaraldehyde (Glutaric dialdehyde, Pentane-1,5-dial) is an aliphatic dialdehyde that can be employed as an effective biochemical reagent for various purposes such as a protein crosslinker, enzyme immobilization in microscopy, histochemistry, and cytochemistry. It serves as an amine-reactive homobifunctional crosslinker and a cell fixative before SDS-PAGE, staining, or electron microscopy, making it suitable for a wide range of morphological studies.

Glutaraldehyde is capable of efficiently crosslinking amine and hydrazine derivatives to proteins and other amine-containing polymers. Notably, in certain reactions, biotin hydrazides have been directly coupled to nucleic acids using glutaraldehyde, presenting a potential utility in conjugating fluorescent hydrazides and hydroxylamines to DNA. In histology studies, Glutaraldehyde is also employed to preserve tissue sections and prepare them for closer examination.

Application

Cross-linking agent for gelatin, poly(vinyl alcohol), and polyheptapeptides.
Glutaraldehyde may be used in the following studies:
  • To compose the fixative solution (Glutaraldehyde + Paraformaldehyde + NaPO4) for use in high-resolution light microscopy and electron microscopy studies.
  • To study the conjugation of goat anti-horseradish peroxidase with alkaline phosphatase by a reported method.
  • To compose the primary fixative, which is employed to protect the deterioration of cytoplasmic features of yeast cells during permanganate fixation.

Features and Benefits

  • Versatile and adaptable for wide variety of research applications
  • Ready-made solution reduces the need for preparation time

Other Notes

For additional information on our range of Biochemicals, please complete this form.
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Supplementary Hazards

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3


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Minutes Int. Symp. Microencapsulation, 9th, 191-191 (1993)
Biomimetics, 1, 219-219 (1992)
Chem. Abstr., 121, 52250t-52250t (1994)
Polymer Journal (1993)
Plastic Embedding and Sectioning of Plant Tissues.
Liu T.
Bio-protocol, 2(23) (2012)

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