P55805
Purine
98%
Synonym(s):
7H-Imidazo(4,5-d)pyrimidine
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About This Item
Empirical Formula (Hill Notation):
C5H4N4
CAS Number:
Molecular Weight:
120.11
Beilstein:
3200
EC Number:
MDL number:
UNSPSC Code:
12352005
PubChem Substance ID:
NACRES:
NA.22
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Quality Level
Assay
98%
form
powder
mp
214-217 °C (lit.)
SMILES string
c1ncc2nc[nH]c2n1
InChI
1S/C5H4N4/c1-4-5(8-2-6-1)9-3-7-4/h1-3H,(H,6,7,8,9)
InChI key
KDCGOANMDULRCW-UHFFFAOYSA-N
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General description
Purine is a heterocyclic organic compound constituting a pyrimidine ring fused to an imidazole ring.
Application
Purine can undergo direct C-H functionalization in the presence of palladium catalyst to form various biologically important products.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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New developments in direct functionalization of C-H and N-H bonds of purine bases via metal catalyzed cross-coupling reactions.
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2'-Fluoro-2'-deoxyguanosine has been reported to have potent anti-influenza virus activity in vitro and in vivo. Herein we describe the synthesis and biological evaluation of 6-modified 2'-fluoro-2'-deoxyguanosine analogues and their corresponding phosphoramidate ProTides as potential anti-influenza virus agents. Whereas the parent
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The Journal of biological chemistry, 288(13), 8977-8990 (2013-02-14)
Leishmania are auxotrophic for purines, and consequently purine acquisition from the host is a requisite nutritional function for the parasite. Both adenylosuccinate synthetase (ADSS) and adenylosuccinate lyase (ASL) have been identified as vital components of purine salvage in Leishmania donovani
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Progress in systems biology offers sophisticated approaches toward a comprehensive understanding of biological systems. Yet, computational analyses are held back due to difficulties in determining suitable model parameter values from experimental data which naturally are subject to biological fluctuations. The
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