T9514
Tetrahydropapaverine hydrochloride
≥90%, powder
Synonym(s):
6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline
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About This Item
Empirical Formula (Hill Notation):
C20H25NO4 · HCl
CAS Number:
Molecular Weight:
379.88
EC Number:
MDL number:
UNSPSC Code:
12352200
Recommended Products
Assay
≥90%
form
powder
color
white
solubility
H2O: soluble
storage temp.
2-8°C
SMILES string
Cl.COc1ccc(CC2NCCc3cc(OC)c(OC)cc23)cc1OC
Biochem/physiol Actions
Phosphodiesterase inhibitor.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Eung Il Kim et al.
Life sciences, 75(16), 1949-1957 (2004-08-13)
The inhibitory effects of tetrahydropapaverine on serotonin biosynthesis in serotonin-producing murine mastocytoma P815 cells were investigated. Tetrahydropapaverine at concentration ranges of 5-20 microM decreased serotonin content in a concentration-dependent manner in P815 cells and showed 42.1% inhibition of serotonin content
F S Messiha
Veterinary and human toxicology, 32(2), 126-130 (1990-04-01)
The effects of tetrahydropapaverine (THP) and papaverine (PAP), an O-methylated analogue, on rat liver alcohol dehydrogenase (L-ADH) and aldehyde-dehydrogenase (L-ALDH) were studied in vitro. The action of THP on these enzymes was also evaluated in vivo in conjunction with its
K Suzuki et al.
Neurochemical research, 15(7), 705-710 (1990-07-01)
Since the discovery of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism, it has been postulated that (a) MPTP-like toxin(s) such as 1,2,3,4-tetrahydroisoquinoline (TIQ) may induce Parkinson's disease. As the neuronal degeneration in MPTP-induced parkinsonism is thought to be caused by the inhibition of the
F S Messiha
Pharmacology, biochemistry, and behavior, 35(1), 29-33 (1990-01-01)
The in vivo effect of amantadine, chlorpromazine and reserpine on testicular aldehyde dehydrogenase (T-ALDH) was studied as a function of mouse strain. The effect of Leu-enkephalin and tetrahydropapaverine on rodent T-ALDH was also studied in vivo. The in vitro effect
S Chulia et al.
British journal of pharmacology, 122(3), 409-416 (1997-11-14)
1. In the present work, the properties of 3-methyl isoquinoline, 3,4-dihydropapaverine, tetrahydropapaverine and tetrahydropapaveroline were compared with those of papaverine and laudanosine. The work includes functional studies on rat isolated aorta contracted with noradrenaline, caffeine or KCl, and a determination
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