T5568

Tyrphostin AG 835

≥92%

• Synonym(s): (+)-(S)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide, Tyrphostin B50
• Empirical Formula (Hill Notation): C₁₈H₁₆N₂O₃
• CAS Number: 133550-37-5
• Molecular Weight: 308.33
• MDL number: MFCD00209855
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278745

Properties

• Assay: ≥92%
• form: crystalline
• potency: IC₅₀ (860 nanomolar for the inhibition of EGFR-kinase activity.)
• solubility: DMSO or ethanol: soluble
• storage temp.: −20°C
• SMILES string: C[C@H](NC(=O)\C(=C\c1ccc(O)c(O)c1)C#N)c2ccccc2
• InChI: 1S/C18H16N2O3/c1-12(14-5-3-2-4-6-14)20-18(23)15(11-19)9-13-7-8-16(21)17(22)10-13/h2-10,12,21-22H,1H3,(H,20,23)/b15-9+/t12-/m0/s1
• InChI key: UMGQVUWXNOJOSJ-DGGAMASNSA-N
• Gene Information: human ... MST1R(4486) , PTK2(5747) , PTK6(5753) , PTK7(5754) , TWF1(5756) , TXK(7294)

Description

Biochem/physiol Actions

Protein tyrosine kinase inhibitor.

Preparation Note

Tyrphostin AG 835 is soluble in ethanol and DMSO.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves