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SRP6530

Sigma-Aldrich

NMNAT1 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym(s):

EC 2.7.7.1, NMN Adenylyltransferase 1, NaMN Adenylyltransferase 1, Nicotinamide Mononucleotide Adenylyl-transferase 1

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

Assay

≥95% (SDS-PAGE)

form

liquid

mol wt

monomer ~333 kDa (Human full-length NMNAT1 aa 1-279 is fused at the N-terminus to a His-tag.)

packaging

pkg of 10 and 50 μg

concentration

1 mg/mL

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... NMNAT1(64802)

General description

This is the nuclear NMNAT isoform. It catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. It can also use the deamidated form of nicotinic acid mononucleotide (NAMN) as substrate with the same efficiency. It interacts with PARP-1/ARTD1. It protects against axonal degeneration following mechanical or toxic insults. It is widely expressed.

Physical form

1 mg/mL in 50 mM sodium phosphate, pH 8.0 containing 300 mM sodium chloride, 2 mM DTT and 10% glycerol.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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