SRP4171
IL-15 from mouse
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Synonym(s):
IL 15, IL-T, Interleukin 15
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About This Item
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biological source
mouse
recombinant
expressed in E. coli
Assay
≥98% (HPLC)
≥98% (SDS-PAGE)
form
lyophilized
mol wt
~13.3 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Il15(16168)
Related Categories
General description
IL15 (interleukin 15) protein is a short-chain α-helical bundle type 1 T cell-stimulating cytokine. It is a pleiotropic cytokine belonging to the cytokine receptor γ chain family, and is expressed by dendritic cells (DCs), epithelial cells, macrophages, monocytes, and fibroblasts. IL15, along with its receptor IL15Rα, are co-expressed majorly by activated monocytes and DCs (dendritic cells). Recombinant mouse IL-15 is a 13.3 kDa protein containing 115 amino acid residues.
Biochem/physiol Actions
IL15 (interleukin 15) and IL2 are the only two known cytokine till date that bind to T-cells through IL-2Rβ (IL2 receptorβ). It interacts with lymphocytes via the heterotrimeric IL-15 receptor (IL-15R) composed of IL-15Rα, IL-2 receptor beta (IL-2Rβ), and IL-2 receptor gamma (IL-2Rγ). Since, IL-2R and IL-15R have common subunits, it is supposed that IL2 and IL15 perform similar functions, such as induction of lymphocyte activation and proliferation in vitro, and apoptosis of activated lymphocytes (AICD). However, unlike IL2, IL15 mimics the function of IFN I (interferon) by potently and selectively activating memory-phenotype CD44hi CD8+ cells.
Physical form
Lyophilized from 10 mM Tris, pH 8.0.
Reconstitution
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 μg/μL. The solution can then be diluted into other aqueous buffers.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells.
Schluns KS, et al.
Journal of Immunology, 168(10), 4827-4831 (2002)
Interleukin-15 Constrains Mucosal T Helper 17 Cell Generation: Influence of Mononuclear Phagocytes.
Yu H, et al.
PLoS ONE, 10(11) (2015)
The shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: implications for cancer therapy.
Waldmann TA
Cancer immunology research, 3(3), 219-227 (2015)
Ai Omi et al.
European journal of immunology, 44(9), 2638-2647 (2014-07-06)
Mature NK cells are heterogeneous as to their expression levels of cell surface molecules. However, the functional differences and physiological roles of each NK-cell subset are not fully understood. In this study, we report that based on the Ly6C expression
Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15.
Zhang X, et al.
Immunity, 8(5), 591-599 (1998)
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