Yes, the material composition is a 1:5 ratio of trimethoprim to sulfamethoxazole. Please see the link below to a publication that may be helpful:
https://link.springer.com/chapter/10.1007/978-3-642-81890-5_11#:~:text=Co%2Dtrimoxazole%20is%20a%20combination,in%20a%201%3A%205%20ratio.
SML3191
Cotrimoxazole
≥98% (HPLC), Antibiotic, powder
Synonym(s):
4-Amino-N-(5-methyl-3-isoxazolyl)-benzenesulfonamide mixt. with 5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine, TMP/SMX, Trimethoprim/sulfamethoxazole
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About This Item
Empirical Formula (Hill Notation):
C14H18N4O3·5C10H11N3O3S
CAS Number:
Molecular Weight:
1556.71
UNSPSC Code:
12352107
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Product Name
Cotrimoxazole, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
[S](=O)(=O)(Nc4n[o]c(c4)C)c3ccc(cc3)N.Nc1nc(c(cn1)Cc2cc(c(c(c2)OC)OC)OC)N
InChI
1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)
InChI key
WZRJTRPJURQBRM-UHFFFAOYSA-N
Biochem/physiol Actions
Cotrimoxazole is a combination antibiotic consisting of one part trimethoprim to five parts sulfamethoxazole that is used to treat a variety of bacterial infections both Gram-positive and Gram-negative. Sulfamethoxazole inhibits bacterial dihydropteroate synthase while trimethoprim inhibits bacterial dihydrofolate reductase, thereby blocking the synthesis of nucleic acids.
combination antibiotic consisting of one part trimethoprim to five parts sulfamethoxazole
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This Item | |||
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| description ≥98% (HPLC) | description Ready Made Solution, 100 mg/mL in DMSO | description United States Pharmacopeia (USP) Reference Standard | description certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland |
| form powder | form ready-to-use solution, liquid | form - | form - |
| assay ≥98% (HPLC) | assay - | assay - | assay - |
| Quality Level 100 | Quality Level 200 | Quality Level - | Quality Level 300 |
| storage temp. −20°C | storage temp. −20°C | storage temp. - | storage temp. 2-8°C |
| solubility DMSO: 2 mg/mL, clear | solubility - | solubility - | solubility - |
| color white to beige | color colorless to faint yellow | color - | color - |
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Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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Bonjour. Dans la partie Description je peux lire "Cotrimoxazole is a combination antibiotic consisting of one part trimethoprim to five parts sulfamethoxazole". Vous pouvez me confirmer ce ratio 1:5 dans la ref SML3191 en particulier svp ? C'est pas 1:19?
1 answer-
Helpful?
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