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SML3021

Sigma-Aldrich

ADLumin-1

≥98% (HPLC)

Synonym(s):

6-((1E,3E)-4-(4-(dimethylamino)phenyl)buta-1,3-dien-1-yl)-2-methylimidazo[1,2-a]pyrazin-3(7H)-one, 6-[4-[4-(Dimethylamino)phenyl]-1,3-butadien-1-yl]-2-methyl-imidazo[1,2-a]pyrazin-3(7H)-one

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About This Item

Empirical Formula (Hill Notation):
C19H20N4O
CAS Number:
2417555-90-7
Molecular Weight:
320.39
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

faint yellow to dark orange

solubility

H2O: 0.1 mg/mL (warmed)

storage temp.

2-8°C

SMILES string

CN(C1=CC=C(C=C1)/C=C/C=C/C2=CN3C(N=C(C3=O)C)=CN2)C

Biochem/physiol Actions

ADLumin-1 brain blood barrier penetrant smart chemiluminescence probe for Aβ (amyloid beta) species. Upon binding to Aβ, ADLumin-1 chemiluminescence dramatically increases and its peak shifts from 590 nm to 540 nm. ADLumin-1 is suitable for in vivo dually-amplify signal via chemiluminescence resonance energy transfer (DAS-CRET) with CRANAD-3 a smart NIRF (near infrared fluorescence imaging) probe for Aβs. Apparently both probes bind to Aβ aggregates in close proximity.
brain blood barrier penetrant smart chemiluminescence probe for Aβ (amyloid beta) species

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000201517
0000201518
0000134459
0000126729
0000134459

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Jing Yang et al.
Nature communications, 11(1), 4052-4052 (2020-08-15)
Turn-on fluorescence imaging is routinely studied; however, turn-on chemiluminescence has been rarely explored for in vivo imaging. Herein, we report the design and validation of chemiluminescence probe ADLumin-1 as a turn-on probe for amyloid beta (Aβ) species. Two-photon imaging indicates

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