SML2951

SGC-CK2-1

≥98% (HPLC)

• Synonym(s): N-(5-(3-Cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-ylamino)-2-methylphenyl)propionamide
• Empirical Formula (Hill Notation): C₂₀H₂₁N₇O
• CAS Number: 2470424-39-4
• Molecular Weight: 375.43
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: [n]21ncc(c2nc(cc1NC4CC4)Nc3cc(c(cc3)C)NC(=O)CC)C#N
• InChI key: YKDZIFFKQUNVHH-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Potent and highly selective casein 2 (CK2, CKII) inhibitor with potent cellular activity, but no antiproliferation efficacy in HCT116 or U-87 MG cancer cultures.

SGC-CK2-1 is a potent and highly selective casein 2 (CK2, CKII) inhibitor (CK2α/CK2α′ IC₅₀ = 4.2/2.3 nM by cell-free enzyme assay; DYRK2 IC₅₀ = 440 nM, IC₅₀≥3.4 μM against 465 other kinases). Unlike less specific CK2 inhibitors, SGC-CK2-1 shows no antiproliferation activity in HCT116 or U-87 MG cancer cultures (up to 10 μM) despite its potent cellular activity (CK2α/CK2α′ IC₅₀ = 36/16 nM by cellular NanoBRET assay).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable