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SML2155

Sigma-Aldrich

TAK-901

≥98% (HPLC)

Synonym(s):

5-[3-(Ethylsulfonyl)phenyl]-3,8-dimethyl-N-(1-methyl-4-piperidinyl)-9H-pyrido[2,3-b]indole-7-carboxamide, TAK 901

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About This Item

Empirical Formula (Hill Notation):
C28H32N4O3S
CAS Number:
934541-31-8
Molecular Weight:
504.64
MDL number:
MFCD18782651
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(CC)c1cc(ccc1)c2c3c([nH]c5ncc(cc53)C)c(c(c2)C(=O)NC4CCN(CC4)C)C

InChI

1S/C28H32N4O3S/c1-5-36(34,35)21-8-6-7-19(14-21)23-15-22(28(33)30-20-9-11-32(4)12-10-20)18(3)26-25(23)24-13-17(2)16-29-27(24)31-26/h6-8,13-16,20H,5,9-12H2,1-4H3,(H,29,31)(H,30,33)

InChI key

WKDACQVEJIVHMZ-UHFFFAOYSA-N

Biochem/physiol Actions

TAK-901 is a potent and tight-binding Aurora B kinase inhibitor. TAK-901 targets multiple kinases in vitro, but appears to mainly target Aurora B in cells and in vivo. TAK-901 suppresses cellular histone H3 phosphorylation and induced polyploidy.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
0000061333
0000061332
0000055012

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Saomi Murai et al.
Anticancer research, 37(2), 437-444 (2017-02-10)
Aurora B kinase plays an essential role in chromosome segregation and cytokinesis, and is dysregulated in many cancer types, making it an attractive therapeutic target. TAK-901 is a potent aurora B inhibitor that showed efficacy in both in vitro and
Frances V Hundley et al.
Molecular cell, 81(6), 1319-1336 (2021-02-05)
The human ubiquitin proteasome system, composed of over 700 ubiquitin ligases (E3s) and deubiquitinases (DUBs), has been difficult to characterize systematically and phenotypically. We performed chemical-genetic CRISPR-Cas9 screens to identify E3s/DUBs whose loss renders cells sensitive or resistant to 41

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